乳腺黏液癌6例临床病理分析

Clinicopathologic Analysis of 6 Cases with Mucinous Carcinoma of Breast

目的：探讨乳腺黏液癌的临床病理特点、免疫表型及其与预后的关系。方法：收集6例乳腺黏液癌的临床病理和免疫组织化学染色资料，并结合文献对该肿瘤的临床病理学特征与鉴别诊断进行分析讨论。结果：6例乳腺黏液癌患者平均发病年龄55.2岁，其中4例为单纯型黏液癌，2例为混合型黏液癌。免疫表型具有激素受体高表达，HER-2、C-erbB-2低表达的特点，Ki-67阳性指数为1%~50%。结论：乳腺黏液癌发病年龄较大，肿瘤生长缓慢，发生转移者少，预后好，单纯型黏液癌预后明显较混合型黏液癌好。激素受体阳性者较阴性者预后好。

Objective：To study the clinical pathological characteristics,mucus breast carcinoma immune phenotype and the relationships between them and prognosis.Method：Data of clinical pathological information and immunohistochemical staining of 6 cases with mucinous carcinoma of breast were collected, and combined with literature the clinical pathological characteristics and differential diagnosis of this tumor were analyzed.Result：The average age of 6 cases with mucinous carcinoma of breast was 55.2 years,including 4 cases with simplex mucous carcinoma,2 cases with mixed mucous carcinoma. Immune phenotype had the characteristics of high hormone receptor expression and the lower expression in HER-2 and C-erbB-2,and the positive index of Ki-67 was from 1%to 50%. Conclusion：Age of onset in mucinous carcinoma of breast is older,and the tumor grow slowly,and the shifts happened are fewer,and prognosis is better,and prognosis of simplex mucous carcinoma is better than that in mixed mucous carcinoma,prognosis of the positive hormone receptor in case is better than that in the negative one.