摘要
目的探讨基质金属蛋白酶-11(MMP-11)和基质金属蛋白酶抑制因子-1(TIMP-1)在结直肠癌组织中的表达及意义。方法采用免疫组织化学方法检测MMP-11及TIMP-1在结直肠癌和正常结直肠黏膜组织中的表达。结果结直肠癌组织中MMP-11和TIMP-1的表达与正常结直肠黏膜组织比较,差异均有统计学意义(P<0.05)。MMP-11的表达与浸润深度、淋巴结转移及Dukes分期有关(P<0.05);TIMP-1的表达与淋巴结转移、Dukes分期有关(P<0.05)。MMP-11表达与TIMP-1表达呈正相关关系(P<0.05)。结论 MMP-11和TIMP-1参与了结直肠癌的发生、发展,可以作为预测结直肠癌浸润和转移的指标。
[ Objective ] To investigate the expressions of matrix metalloproteinase-11（MMP-11） and tissue inhibitor of metalloproteinase-1（TIMP-1） in colorectal carcinoma. [ Methods ] The expressions of MMP-11 and TIMP-1 in eolorectal carcinoma tissue and normal colorectal mueosa were studied by immunohistoehemistry. [ Resluts ] The differences of expression of MMP-11 and TIMP-1 were significant between eolorectal carcinoma tissue and normal colorectal mucosa （P〈0.05）; Expressions of MMP-11 was correlated with depth of tumor invasion, LN mestasis and Dukes stage（P〈0.05） ; Expression of TIMP-1 was correlated with LN mestasis and Dukes stage（P〈0.05）; Positive correlation between MMP-11 and TIMP-1 was observed（P〈0.05）. [ Conclusion ] MMP-11 and TIMP-1 play a role in the generation and development of colorectal carcinoma, and may be markers to predict the progression and metastasis of colorectal carcinoma.
出处
《中国医学工程》
2014年第1期9-10,共2页
China Medical Engineering
