新疆不同民族中HBVDNA与Pers_2Ag/Pers_2Ab的相关性分析

The correlation analysis of HBVDNA and Pers_2Ag/Pers_2Ab among various national groups in Xinjiang

目的了解新疆地区汉、维、哈、回、蒙古族乙型肝炎病毒感染者血清中HBVDNA与PreS2Ag、PreS2Ab之间的关系。方法应用全自动荧光定量PCR法定量检测各民族HBV阳性血清HBVDNA,分成HBVDNA+组(阳性组);HBVDNA-组(阴性组),并分别进行了PreS2Ag/PreS2Ab检测。结果在新疆地区177例HBVDNA+组中,PreS2Ag阳性157例,PreS2Ab阳性10例,阳性率分别为88.70%和5.65%;在140例HBVDNA-组中,PreS2Ag阳性112例,PreS2Ab阳性14例,阳性率为80.00%、10.00%。结论在新疆各民族之间,HBV感染者血清HBVDNA+组和HBVDNA-组中的PreS2Ag的阳性率,经统计学处理后,χ2<3.84、P>0.05,无显著性差异。在HBVDNA-组中,仅有汉族与哈族,维族与哈族中PreS2Ab的阳性率的比较,χ2=13.78和9.00,P<0.005,有显著性差异。

[ Objective ] To acquaint with the correlation of HBVDNA and Pers2Ag/Pers2Ab in serum of HBV infected people among Han people, Uigur, Kazak, Hui and Mongolia in Xinjiang. [ Methods ] Positive serum samples from different nations in xinjiang were divided into HBVDNA＋ group and HBVDNA- group by real time-PCR, meanwhile, PreS2Ag/ PreS2Ab of samples were detected respectively. [ Resluts ] Positive rates of PreS2Ag and PreS2Ab in HBVDNA＋ group were 88.70% and 5.65%, while numbers were 80.00% and 10.00% in HBVDNA- group. [ Conclusion ] By statistical treatment, the positive rate of PreS2Ag had no significant difference between HBVDNA＋ group and HBVDNA-group in HBV infected serum samples from those nations in xinjiang（χ^2〈3.84, P〉0.05）. In HBVDNA- group, two groups positive rates of PreS2Ab had significant difference： One was the rate between Han people and Kazakfx2=13.78, P〈0.005）, the other was the rate between Uiger and Kazak（χ^2=9.00, P〈0.005）.