奥氮平与利培酮治疗冰毒所致精神障碍的临床对照研究

Clinical controlled study on the effect of olanzapine and risperidone in the treatment of mental disorder caused by methamphetamine(meth)

目的观察奥氮平与利培酮治疗甲基苯丙胺(冰毒)所致精神障碍的疗效和不良反应。方法对我科2011年1月至2012年12月收治的98例符合中国精神疾病分类方案与诊断标准第三版(CCMD-3)诊断为冰毒所致精神障碍的患者,随机分为2组:奥氮平组49例和利培酮组49例,采用阳性与阴性症状量表(PANSS)和不良反应量表(TESS)评定患者的疗效和不良反应。结果奥氮平组有效率为93.8%,利培酮组有效率为89.7%。两组疗效比较差异无统计学意义(P>0.05)。两组不良反应发生率比较差异有统计学意义(P<0.05),主要表现在锥体外系不良反应及镇静。结论奥氮平、利培酮均能有效改善冰毒所致的精神病性症状,疗效显著。但奥氮平不良反应发生率低,安全性好。

Objective To observe the curative effect and adverse effect of olanzapine and risperidone in the treatment of mental disorder caused by methamphetamine （meth）. Methods 98 cases of patients diagnosed mental disorder caused by methamphetamine according to Chinese Classification of Mental Disorders-3 in our department from January 2011 to December 2012 were randomly divided into two groups ：olanzapine group （n = 49 ） and the risperidone group （ n = 49）. The curative effect and adverse effect of the two groups were assessed by positive and negative syn- drome scale （PANSS） and treatment emergent symptom scale （ TESS）. Results The effective rate of the olanzapine group was 93.8 %, while the effective rate of the risperidone group was 89. 7%. There was no significant difference be- tween the two groups （ P 〉 0. 05 ）. There was significant difference of the adverse effects between the two groups （ P 〈 0. 05 ）, they mainly manifested as extrapyramidal side effects and calm. Conclusion Both olanzapine and risperidone can improve psychotic symptoms caused by methamphetamine, but the adverse effect of olanzapine is low, and it is safe.