氧驱雾化吸入布地奈德混悬液在小儿支气管哮喘急性发作期的应用

Clinical efficacy of oxygen flooding budesonide inhalation suspension in children with acute exacerbation of bronchial asthma

目的观察氧气驱动(氧驱)雾化吸入治疗小儿支气管哮喘急性发作的临床效果。方法选取我院儿科门诊诊治的112例支气管哮喘急性发作的患儿,采用信封法随机分为2组,每组56例。对照组患儿采用支气管哮喘急性发作常规治疗,包括抗感染、止咳、化痰等对症支持治疗;观察组患儿在对照组基础上,采用氧驱雾化呼入布地奈德混悬液。治疗4 d后,仔细观察两组患儿咳嗽、呼吸困难等临床症状改善情况及肺部哮鸣音改善情况,并根据患儿各项症状、体征改善情况进行疗效评定。结果观察组患儿在氧驱雾化吸入治疗过程中,未见明显不良反应,均能顺利完成治疗。观察组、对照组的治疗总有效率分别为96.43%、85.71%,两组比较差异有统计学意义(P<0.05)。结论对于小儿支气管哮喘急性发作期患儿,采用常规综合治疗基础上加用氧驱雾化吸入布地奈德混悬液治疗,可取得满意的效果,而且患儿耐受性好。

Objective To observe the effect of oxygen drive （oxygen flooding） inhalation treatment for chil- dren with acute exacerbation of bronchial asthma. Methods 112 children with acute exacerbation of bronchial asthma in hospital were randomly divided into two groups by envelope method, 56 cases in each group. Patients in control group were treated with conventional treatment including anti-infective, cough, phlegm and other symptomatic and sup- portive treatment, patients in observation groups were given oxygen flooding atomization incoming budesonide on the basis of control group. After 4 d of treatment, the coughing, breathing difficulty and other clinical symptoms and wheez- ing lungs were observed, and the efficacy of the two groups was evaluated closely according to the improvement of vari- ous symptoms and signs. Results No significant adverse reaction was found in the patients of the two groups, all the children could complete the treatment successfully. The total effective rate of observation group and control group were 96. 43 % and 85.71% , there were significant differences between the two groups （ P 〈 0. 05 ）. Conclusion Conven- tional therapy combined with oxygen flooding budesonide inhalation therapy has satisfactory effect on children with a- cute exacerbation of bronchial asthma and with good tolerance of children.