174张门急诊处方超适应证使用质子泵抑制剂的合理性分析

Analysis on rationality of 174 prescriptions with proton pump inhibitors off-label used in outpatient and emergency department

目的对口服质子泵抑制剂(PPI)的超适应证使用情况进行分析,为合理用药提供参考。方法调取我院2011年11月12日-15日期间含PPI的门、急诊处方,分析PPI超适应证使用情况,并对PPI在消化与非消化内科间超适应证使用的合理性进行比较。结果超适应证处方174张,其中合理处方134张(占77.0%)。超适应证处方中的PPI以奥美拉唑肠溶胶囊为主(76张,占43.7%),埃索美拉唑镁肠溶片次之(40张,占23.0%)。非消化内科超适应证使用PPI以奥美拉唑肠溶胶囊为主(占67.1%),消化内科以其他PPI为主(占62.2%),两者的品种选择差异有统计学意义(χ2=14.456,P<0.01)。消化内科超适应证使用PPI的合理性优于非消化内科(χ2=6.788,P<0.01)。结论超适应证使用口服PPI,消化内科处方更合理。

Objective To analyze the rationality of off-label uses of oral proton pump inhibitors （PPI） , so as to provide references for the rational use of PPI. Methods Prescriptions containing oral PPI in outpatient and emergen- cy departments in our hospital from 12 to 15 November,2011 were collected,prescriptions of off-label uses were coun- ted according to drug descriptions. Rationality of off-label uses of oral PPI was compared between digestive medicineand non-digestive medicine. Results In 174 prescriptions of off-label uses, reasonable prescriptions were 134 pieces （77%） ;prescriptions containing omeprazole enteric-coated capsules were 76 pieces （43.7%）, containing esome- prazole magnesium enteric-coated tablets were 40 pieces （23%）. The off-label uses of PPI in non-digestive medicine was mainly omeprazole enteric-coated capsules （67. 1% ） , digestive medicine was mainly other PPI （62. 2% ） , there was significant difference in variety selection （X2 = 14. 456 ,P 〈 0. 01 ）. Rationality of off-label uses of oral PPI in di- gestive medicine was better than that in non-digestive medicine （X2 = 6. 788, P 〈 0. 01 ）. Conclusion In off-label uses of oral PPI, prescription of digestive medicine is more reasonable.