抗糖尿病治疗对骨组织的安全性

Safety of antidiabetic therapies on bone

糖尿病与骨质疏松都是代谢性疾病,患病机制有着密切联系。糖尿病能引起骨质疏松,而抗糖尿病治疗从分子水平和能量代谢的角度也会对骨组织产生影响。本文综述了抗糖尿病治疗对骨组织影响的相关证据和可能的病理机制,为临床安全用药提供参考。

Objective Osteoporosis and diabetes share many features including genetic predispositions and molecular mechanisms. The linkage between the two chronic diseases, which stems from overlapping molecular controls involved in bone homeostasis and energy metabolism, creates a possibility that certain antidiabetic therapies may affect bone. Bone should be considered as a vital target for therapies that modulate energy metabolism. This review is summa- rizing available data on the skeletal effects of clinically approved antidiabefic therapies.