249例前列腺液细菌培养及药敏结果分析

Analysis of bacterial culture and drug sensitivity results of 249 prostate fluid samples

目的分析前列腺液细菌培养结果，探索细菌感染在慢性细菌性前列腺炎病因学中的意义，对临床慢性细菌性前列腺炎的治疗提供参考。方法嘱前列腺炎患者停用抗生素3d以上，清洗尿道外口，按摩前列腺液作细菌培养及药敏试验。结果249份前列腺液标本中，98份细菌培养阳性，阳性率39．4％。检出细菌98株，其中革兰阳性菌92株，占93．9％，革兰阴性杆菌6株，占6．1％。78株葡萄球菌的体外药敏试验结果显示，仅对万古霉素、利奈唑胺和替考拉宁敏感，而对青霉素、阿奇霉素、红霉素和克拉霉素全部耐药。对其他种类抗生素亦有不同程度的耐药。6株革兰阴性杆菌药敏结果显示，对常见的抗生素均敏感。结论革兰阳性葡萄球菌及棒状杆菌可能在慢性细菌性前列腺炎病原学中占有一定比例，抗生素的耐药性应引起高度重视。

Objective To analyze bacterial culture results of prostate fluid samples and explore the etiological significance of bacterial infection for clinical treatment of chronic bacterial prostatitis. Methods Patients with prostatitis were asked to stop antibiotics treatment for more than 3 days and clean their external orifice of urethra prior to prostatic fluid collecting. Prostatic fluid samples were collected for bacterial culture and drug sensitivity test. Results In all 249 prostatic fluid samples, 98 of them showed positive result in bacterial culture. The positive rate was 39.4%, including 92 strains of Gram-positive Bacterial strains, accounting for 93.9%, 6 strains of Gram-negative bacterial strains, accounting for 6.1%. Drug sensitivity results from 78 cases of staphylococcal strains showed they were sensitive to vancomycin, linezolid and teicoplanin, but resistant to penicilinc, azithromycin, erythromycin, clarithromycin and other antibiotics. Drug sensitivity results from 6 strains of gram negative bacterial showed they were sensitive to common antibiotics. Conclusion Gram positive Staphylococcus and Corynebacterium may play an important role in the pathogenesis of chronic bacterial prostatitis, antibiotic resistance deserves to bemore attention.