响应曲面法优化防腐剂对羟基苯甲酸甲酯合成新工艺

Optimization of synthesis conditions of novel process methylparaben by response surface methodology

以对羟基苯甲酸和甲醇在氨基磺酸催化下反应得到对羟基苯甲酸甲酯。通过响应曲面法优化了反应的条件,得到对羟基苯甲酸甲酯合成的最佳工艺为(以对羟基苯甲酸为0.1mol为准):醇与酸的摩尔比为5.3,氨基磺酸投加量为2.3g,反应时间为6h 20min,反应温度为65℃。在此最佳条件下,产率可达90.5%。

Methylparaben is synthesized by hydroxybenzoic acid and methanol under the catalytic reaction of sulfamic acid. Response surface methodology is used to optimize the reaction conditions, the best process methylparaben synthe- sis is as follows （take p- hydroxybenzoic acid of 0. lmol as basis） ： the molar ratio of methanol and hydroxybenzoic acid is 5. 3, the dosage of sulfamic acid 2. 3g, the reaction time is 6h 20min, the reaction temperature is 65℃. Under the optimal conditions, the yield is 90. 5%.