期刊文献+

糖尿病与口腔扁平苔藓相关性分析 被引量:1

Analysis of the relationship between diabetes mellitus and oral lichen planus
原文传递
导出
摘要 目的探讨糖尿病与口腔扁平苔藓(OLP)的相关性。方法应用国内外数据库检索相关文献,将纳入文献分为A、B两组:A组是OLP患者中糖尿病患病为结局指标的文献;B组是糖尿病患者中OLP患病为结局指标的文献。采用RevMan5.1软件分别对A、B组相关数据进行Meta分析,评价糖尿病与OLP之间的相关性。结果共纳入15项研究,其中A组8项研究,病例1123例,正常对照1292例;B组7项研究,病例3652例,正常对照2618例。A组糖尿病患病合并OR值及95%CI为1.83(1.24,2.69),OLP组糖尿病患病率明显高于对照组,且差异有统计学意义(P=0.0002);B组OLP患病合并OR值及95%CI为2.25(1.34,3.78),糖尿病组OLP的患病率明显高于对照组,且差异有统计学意义(P=0.002)。结论糖尿病与OLP之间存在明显关联。在治疗OLP时需关注患者是否患有糖尿病,同期治疗糖尿病对OLP的疗效有重要作用。对于糖尿病患者,加强口腔宣教,定期进行口腔检查,及时发现并治疗OLP十分必要。 Objective To assess the associations between diabetes mellitus and oral lichen planus. Methods Retrieve the relevant literature from domestic and international databases and divide them into A,B groups. Group A consisted of literature about the prevalence of diabetes mellitus(DM)in patients with oral lichen planus(OLP)and group B consisted of literature about the prevalence of oral lichen planus in patients with diabetes mellitus. Meta-analysis of group A and B data was performed to estimate the pooled odds ratio(OR)and 95% confidence intervals(CIs)to evaluate the relationship between OLP and DM,respectively. Results A total of 15 case-control studies were included,among which 8 studies belonged to group A,and the others belonged to group B. There were 1123 OLP patients and 1292 controls in group A. The prevalence of DM was significantly higher in patients with OLP than in controls,with a resulting pooled OR of 1.83 (95% CI = 1.24 to 2.69;P 〈 0.001). There were 3652 OLP patients and 2618 controls in group B. The prevalence of OLP was significantly higher in patients with DM than in controls,with a resulting pooled OR of 2.25(95% CI = 1.34 to 3.78;P 〈 0.001). Conclusion Oral lichen planus has significant association with diabetes mellitus. It’s important to be concerned about DM conditions in patients with OLP. Regular oral examination is also needed for patients with DM.
出处 《中国实用口腔科杂志》 CAS 2014年第2期96-100,104,共6页 Chinese Journal of Practical Stomatology
关键词 口腔扁平苔藓 糖尿病 META分析 病例对照研究 oral lichen planus, OLP diabetes mellitus Meta-analysis case-control study
  • 相关文献

参考文献20

  • 1Ahmed I,Nasreen S,Jehangir U. Frequency of oral lichen planus in patients with noninsulin dependent diabetes mellitus[J].Journal of Pakistan Association of Dermatologists,2012.30-34.
  • 2陈谦明.口腔黏膜病学[M]北京:人民卫生出版社,2008101-107.
  • 3Ali AA,Suresh CS. Oral lichen planus in relation to transaminase levels and hepatitis C virus[J].Journal of Oral Pathology and Medicine,2007.604-608.
  • 4Albrecht M,Banoczy J,Dinya E. Occurrence of oral leukoplakia and lichen planus in diabetes mellitus[J].Journal of Oral Pathology and Medicine,1992.364-366.
  • 5Bajaj DR,Khoso NA,Devrajani BR. Oral lichen planus:a clinical study[J].Journal of the College of Physicians and Surgeons Pakistan,2010.154-157.
  • 6Gorsky M,Raviv M,Moskona D. Clinical characteristics and treatment of patients with oral lichen planus in Israel[J].Oral Surgery,Oral Medicine,Oral Pathology,Oral Radiology and Endodontics,1996.644-649.
  • 7于静涛,王惠琼,邸秋媛.口腔扁平苔藓与糖尿病及循环免疫复合物关系的研究[J].临床口腔医学杂志,1992,8(3):138-139. 被引量:5
  • 8Xue JL,Fan MW,Wang SZ. A clinical study of 674 patients with oral lichen planus in China[J].Journal of Oral Pathology and Medicine,2005.467-672.
  • 9Seyhan M,Ozcan H,Sahin I. High prevalence of glucose metabolism disturbance in patients with lichen planus[J].Diabetes Research and Clinical Practice,2007.198-202.
  • 10唐国瑶,许国祺.口腔扁平苔藓患者空腹血糖测定及评价[J].实用口腔医学杂志,1997,13(2):94-96. 被引量:9

二级参考文献10

  • 1陈谦明.口腔粘膜病学[M].3版.北京:人民卫生出版社,2008:103—104.
  • 2Lundstrom IM. Incidence of diabetes mellitus in patients with oral lichen planus [J]. Int J Oral Surg, 1983, 12(3) : 147 -152.
  • 3Pickup JC, Chusney GD, Thomas SM, et al. Plasma interleukin- 6, tumor necrosis factor alpha and blood cytokine production in type 2 diabetes[J]. Life Sci, 2000, 67(3) : 291 -300.
  • 4Rhodus NL, Cheng B, Myers S, et al. The feasibility of monitoring NF-kappaB associated cytokines : TNF-alpha, IL-1 alpha, IL- 6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus[J]. Mol Carcinog, 2005, 44(2): 77 -82.
  • 5Gu GM, Martin MD, Darveau RP, et al. Oral and serum IL-6 levels in oral lichen planus patients [ J ]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2004, 98 (6) : 673 - 678.
  • 6Rhodus NL, Cheng B, Bowles W, et al. Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone[J]. Oral Dis, 2006, 12(2) : 112 - 116.
  • 7Sun A, Chia JS, Chang YF, et al. Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus[ J]. J Oral Pathol Med, 2002, 31 (4) : 196 -203.
  • 8Sklavounou-Andrikopoulou A, Chrysomali E, lakovou M, et al. Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas /Apo-1 and Bcl-2 in oral lichen planus [ J ]. J Oral Pathol Med, 2004, 33(7) : 386 -390.
  • 9Philip A, Subramanian R, Chunling L, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance [ J ]. Am J Physiol Endocrinol Metab, 2001, 280(5) : E745 -751.
  • 10叶任高.内科学[M]5版[M].北京:人民卫生出版社,2002.862.

共引文献16

同被引文献34

  • 1唐国瑶,许国祺.口腔扁平苔藓患者空腹血糖测定及评价[J].实用口腔医学杂志,1997,13(2):94-96. 被引量:9
  • 2Eisen D,Carrozzo M,Bagan Sebastian JY,et al.Number Y Oral lichen planus:clinical features and management[J].Oral Dis,2005,11(6):338-349.
  • 3Escudier M,Ahmed N,Shirlaw P,et al.A scoring system for mucosal disease severity with special reference to oral lichen pla- nus[J].BrJ Dermatol,2007,157(4):765-770.
  • 4Wamakulasuriya S,Johnson NW,van der Waal I.Nomencla- ture and classification of Potentially malignant disorders of the oral mucosa[J].J Oral Pathol Med,2007,36(10):575-580.
  • 5Fitzpatrick SG,Hirsch SA,Gordon SC.The malignant transfor- mation of oral lichen planus and oral lichenoid lesions:a system- atic review[J].J Am Dent Assoc,2014,145(1):45-56.
  • 6Lozada-Nur F,Miranda C.Oral lichen planus:epidemiology,clinical characteristics,and associated diseases[J].Semin Cu- tan Med Surg,1997,16(4):273-277.
  • 7Sugerman PB,Savage NW.Oral lichen planus:causes,diagno- sis and management[J].Aust Dent J,2002,47(4):290-297.
  • 8Keamey PM,Whelton M,Reynolds K,et al.Global burden of hypertension:analysis of worldwide data[J].Lancet,2005,365(9455):217-223.
  • 9Grinspan D,Diaz J,Villapol LO,et al.Lichen ruber planus of the buccal mucosa.Its association with diabetes[J].Bull Soc Fr Dermatol Syphiligr,1966,73(6):898-899.
  • 10陈海琼,许国祺,范献群,等.口腔粘膜扁平苔藓与系统疾病关系的初步探讨[J].口腔医学,1982,2(2):86-88.

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部