糖尿病与口腔扁平苔藓相关性分析

Analysis of the relationship between diabetes mellitus and oral lichen planus

目的探讨糖尿病与口腔扁平苔藓(OLP)的相关性。方法应用国内外数据库检索相关文献,将纳入文献分为A、B两组:A组是OLP患者中糖尿病患病为结局指标的文献;B组是糖尿病患者中OLP患病为结局指标的文献。采用RevMan5.1软件分别对A、B组相关数据进行Meta分析,评价糖尿病与OLP之间的相关性。结果共纳入15项研究,其中A组8项研究,病例1123例,正常对照1292例;B组7项研究,病例3652例,正常对照2618例。A组糖尿病患病合并OR值及95%CI为1.83(1.24,2.69),OLP组糖尿病患病率明显高于对照组,且差异有统计学意义(P=0.0002);B组OLP患病合并OR值及95%CI为2.25(1.34,3.78),糖尿病组OLP的患病率明显高于对照组,且差异有统计学意义(P=0.002)。结论糖尿病与OLP之间存在明显关联。在治疗OLP时需关注患者是否患有糖尿病,同期治疗糖尿病对OLP的疗效有重要作用。对于糖尿病患者,加强口腔宣教,定期进行口腔检查,及时发现并治疗OLP十分必要。

Objective To assess the associations between diabetes mellitus and oral lichen planus. Methods Retrieve the relevant literature from domestic and international databases and divide them into A,B groups. Group A consisted of literature about the prevalence of diabetes mellitus（DM）in patients with oral lichen planus（OLP）and group B consisted of literature about the prevalence of oral lichen planus in patients with diabetes mellitus. Meta-analysis of group A and B data was performed to estimate the pooled odds ratio（OR）and 95% confidence intervals（CIs）to evaluate the relationship between OLP and DM,respectively. Results A total of 15 case-control studies were included,among which 8 studies belonged to group A,and the others belonged to group B. There were 1123 OLP patients and 1292 controls in group A. The prevalence of DM was significantly higher in patients with OLP than in controls,with a resulting pooled OR of 1.83 （95% CI = 1.24 to 2.69;P 〈 0.001）. There were 3652 OLP patients and 2618 controls in group B. The prevalence of OLP was significantly higher in patients with DM than in controls,with a resulting pooled OR of 2.25（95% CI = 1.34 to 3.78;P 〈 0.001）. Conclusion Oral lichen planus has significant association with diabetes mellitus. It’s important to be concerned about DM conditions in patients with OLP. Regular oral examination is also needed for patients with DM.