小剂量阿司匹林口服对乳腺癌患者PICC置管后血栓预防的影响

Effect of low-dose aspirin orally on thrombosis prevention in breast cancer patients after PICC catheter

目的：观察阿司匹林预防乳腺癌患者PICC置管后静脉血栓形成的临床效果。方法采用随机数字表法将256例行PICC穿刺的乳腺癌患者分为观察组（128例）和对照组（128例）。两组均按照常规方法进行PICC置管及日常维护，观察组给予阿司匹林100 mg口服，1次/d，对照组未使用任何抗凝药物。通过临床观察及彩色多普勒血流显像判断患者静脉血栓形成情况，同时观察患者不良反应的发生情况。结果观察组患者的静脉血栓发生率为3．1％，低于对照组的9．4％，两组比较差异有统计学意义（χ2＝3．919，P＜0．05）。观察组患者无显著过敏、血小板减少及出血倾向等不良反应发生。结论口服阿司匹林肠溶片可有效地预防乳腺癌患者PICC置管后静脉血栓的形成。

Objective To observe the clinical effect of aspirin on venous thrombosis in breast cancer patients after peripherally inserted central venous catheter （ PICC ） .Methods Two hundred fifty-sixty breast cancer patients with PICC were divided into the observation group and the control group according the random number table, each with 128 cases. The two groups all received the conventional PICC catheter and maintenance, the observation group received the oral administer of aspirin 100 mg for 28 day, once a day, and the control group did not take any anticoagulation drugs .The venous thrombosis was checked by the clinical observation and color Doppler flow imaging in two groups , and the adverse reactions were also observed in patients.Results The incidence rate of venous thrombosis was 3.1%in the observation group , and was lower than 9.4%in the control group, and the difference was statistically significant （χ2 =3.919, P＆lt;0.05）.The adverse reactions including obvious allergy , thrombocytopenia and bleeding tendency were not found in the observation group .Conclusions Oral aspirin enteric-coated tablets can effectively prevent venous thrombosis in breast cancer patients after PICC .