摘要
儿童和青少年DTC发病率不高，但与成人DTC相比，具有一些鲜明的特征：发现时病灶体积较大，诊断时多出现颈部淋巴结或远处转移，肿瘤细胞NIS表达增高，治疗后复发率高，但总体存活率较高。术后^131I治疗是治疗儿童和青少年DTC的重要手段。目前^131I治疗主要采用以下3种剂量模式：不引起骨髓抑制的最大剂量，可去除病灶的特定剂量和固定剂量。
The occurrence rate of DTC in children and adolescents is not high. However, DTC in these patients has some distinct characteristics different from those in adult, such as larger tumor volume at diagnosis, early invasion of neck lymph nodes and early distant metastases, high NIS expression, high re- currence but higher overall survival rate. 131I ablation is still one of the important treatment methods after surgery. Currently, there are 3 major dosage regimens adopted for 131I treatment： prescribed dose without causing bone marrow suppression/toxicity, dose aiming at tumor ablation, and empirically fixed dose.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2014年第1期76-78,共3页
Chinese Journal of Nuclear Medicine and Molecular Imaging
