针刺穴位脑功能磁共振成像的再研究

Reinvestigation of of fMRI results by acupuncture stimulation

目的利用功能磁共振成像(functional Magnetic Resonance Imaging,fMRI)针刺位于足少阴肾经上的太溪穴(KI3)及非穴位对照点进行多次脑fMRI,探讨针刺引起的脑功能变化。方法选取健康志愿者10名,在不同时间进行4次完全相同的功能磁共振扫描,每次扫描间隔至少间隔两周。结果针刺太溪穴及非穴位点均可以观察到脑功能的活动。针刺两点同一受试者在不同次实验中及同一次实验过程中不同个体间的BOLD信号均有较大变异,但同一次实验中所有志愿者组分析结果相对恒定;组分析结果显示针刺太溪与非穴位点引起的脑功能活动有明显差别。结论应用fMRI来研究针刺脑功能活动,为了解针刺某特定穴位点特定个体脑激活模式,需行多个时相的功能磁共振扫描,以获得精确的脑激活模式图像。

Objective To test the fMRI （functional magnetic resonance imaging） signal changes evoked by acupuncture stimulation on acupoints of Taixi （KI3） and an false acupoints.Methods Ten volunteers participated in fouridentical scanning sessions in various time with the interval at least two weeks.Results Signal changes were observed during acupuncture at KI3 and false acupoint.Despite of the variability across individual sessions and volunteers,average data from each experimental session were more similar.Conclusion To accurately capture the activation patterns evoked by acupuncture stimulation at a particular point for a specific subject,multiple sessions should be performed.