新生儿脐血葡萄糖-6-磷酸脱氢酶缺乏症7531例筛查结果分析

Analysis on the screening results of glucose-6-phosphate dehydrogenase deficiency in umbilical cord blood for 7531 newborns

目的通过对新生儿葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的筛查,了解揭西县新生儿葡萄糖-6-磷酸脱氢酶缺乏症的发病情况,提高对此病的认识,避免诱发此病。方法使用BS-200全自动生化分析仪对7531例新生儿脐血进行G6PD定量检测(速率法)。结果筛查7531例,阳性420例,阳性率为5.6%。男性4357例,阳性294例,占男性受检人数的6.7%(294/4357);女性3156例,阳性126例,占女性受检人数的3.9%(126/3156)。男性重度缺乏占74.8%,轻度缺乏占25.2%,女性重度缺乏占18.3%,轻度缺乏占81.7%。结论揭西县新生儿G6PD缺乏症发生率为5.6%,男性患者明显多于女性患者,男性多为重度缺乏,女性多为轻度缺乏。为G6PD缺乏症的新生儿100%发放G6PD缺乏症健康处方,提高预防意识,避免诱发此病。

Objective To understand the morbidity of neonatal glucose-6-phosphate dehydrogenase（G6PD） deficiency in Jiexi county via the screening of G6PD deficiency among newborns, and to improve people＇s knowledge of the disease which can be prevented and avoided. Methods G6PD of the umbilical cord blood of 7531 newborns were quantitatively measured via BS-200 automatic biochemical analyzer. Results 420 of the 7531 screened newborns were positive, and the positive rate was 5.6%.294 of the 4357 male newborns were positive,accounting for 6.7% of the male total（294/4357）.126 of the 3156 female newborns were positive, accounting for 3.9% of the female total（126/3156）.Severe deficiency in male newborns accounted for 74.8% of the total,and mild deficiency 25.2%. Severe deficiency in female newborns accounted for 18.3% of the total, and mile deficiency 81.7%. Conclusion The incidence rate of G6PD deficiency in Jiexi county is 5.6%, in which male patients are significantly more than female ones. Male majority are severe deficiency while female majority are mild deficiency. Health prescriptions are distributed to 100% of newborns with G6PD deficiency. People＇s awareness of prevention should be raised so as to avoid the disease.