银杏叶片改善轻度认知障碍患者记忆商的临床观察

Ginkgo Leaves Tablet Improved the Memory Quotient of Patients with Mild Cognitive Impairment: a Clinical Observation

目的观察银杏叶片对轻度认知障碍(mild cognitive impairment,MCI)患者记忆商的影响。方法将符合纳入标准的113例患者随机分为对照组(55例)和治疗组(58例)。对照组给予健康宣教、运动锻炼、饮食调摄等干预措施;治疗组在对照组治疗措施的基础上给予口服银杏叶片,每次19.2 mg,每天3次。两组均治疗1年,于治疗前、治疗6个月、治疗1年时采用修订韦氏记忆量表中文版(WMS-RC)进行记忆商(memory quotient,MQ)的评估。结果治疗组治疗0.5、1年后,MQ分值升高,与治疗前及对照组同期比较,差异均有统计学意义(P<0.05);MQ有效率(分别为48.28%、50.00%)明显升高,与对照组(分别为30.91%、27.27%)比较,差异亦有统计学意义(P<0.05,P<0.01)。在治疗0.5、1年后,与对照组同期比较,治疗组再认、再生、理解、背数分值差异均有统计学意义(P<0.05,P<0.01)。结论银杏叶片具有较好的提高MCI患者MQ的功效,尤其是在提高再认、再生、理解、背数方面表现更加显著。

Objective To observe the effect of Ginkgo Leaves Tablet （GLT） on memory quotient （MQ） of mild cognitive impairment （MCI） patients. Methods One hundred and thirteen patients were randomly assigned to the control group （55 cases） and the treatment group （58 cases）. Patients in the control group received dietetic therapy and physical exercises, while those in the treatment group addi- tionally took GLT, 19.2 mg each time, three times daily. The treatment course was 12 months for all. The MQ of all the patients was assessed by WMS-RC before treatment, at 6-month of treatment, and 12-month of treatment. Results Compared with the control group, the improvement of MQ increased in the treat- ment group 0.5 and 1 year after treatment （P 〈0.05）. The clinical efficiency of MQ obviously increased in the treatment group （48.28% and 50.00% ）, showing statistical difference when compared with the con- trol group （30.91% and 27.27%, P 〈0.05, P 〈0.01）. There was statistical difference in added scores of recognition, regeneration, understanding, and recitation test at 6-month of treatment and 12-month of treatment between the treatment group and the control group （P 〈0.05, P 〈0.01 ）. Conclusion GLT was effective in improving MQ of MCI patients, especially in improving recognition, regeneration, understand- ing, and recitation test.