皮肤抗氧化功效评价动物模型及替代方法

Animal model and alternative test to skin antioxidant efficacy assessment

氧化应激和损伤与多种皮肤功能下降和皮肤疾病密切相关。传统皮肤抗氧化剂的生物学评价多采用局部皮肤损伤模型或疾病动物模型,随着皮肤氧化损伤机制的认识不断深入和体外培养技术的发展,利用体外培养的皮肤细胞或重建的皮肤模型为测试系统,建立新型快速检测方法,可用于抗氧化效应评价和筛查,以及机制研究和产品开发。

Oxidative stress and damage is closely related to skin functional decreased and diseases. Traditional biological evaluation of the skin antioxidant often use animal model through creative a model of local skin injury or disease. With the deepening understanding of the mechanism of skin oxidative damage and the development of in vitro culture techniques, using cultured skin cells or reconstructive skin model test system can be establish a new rapid testing method which can be used in the evaluation and screening of antioxidant effects, as well as mechanisms research and product development.