利培酮与奥氮平对精神分裂症急性期的疗效及临床影响因素的比较

Comparison of curative effect and clinical influence factors of risperidone and olanzapine in the treatment of acute phrase of schizophrenia

目的：比较利培酮、奥氮平治疗精神分裂症急性期的疗效及临床影响因素。方法：利培酮组27例，剂量范围2～6mg／d，奥氮平组26例，剂量范围10～20mg／d。两组均以阳性与阴性症状评定量表（PANSS）观察6周，治疗前收集患者的性别、年龄、病程，治疗中准确记录患者用药情况。结果：6周末，利培酮与奥氮平治疗精神分裂症急性期的有效率均为84．6％；奥氮平组患者在一般病理症状、阳性症状中的疗效优于利培酮组患者（P〈0．05）；治疗时间长，利培酮、奥氮平治疗精神分裂症急性期的疗效增加（P〈0．05）；治疗时间与利培酮、奥氮平不存在交互作用（P〉0．05）；治疗时间、病程、剂量对利培酮的疗效有影响（P〈0．05），治疗时间对奥氮平的疗效有影响（P〈0．05）。结论：精神分裂症的急性期，奥氮平的疗效与利培酮相当，但奥氮平疗效的稳定性优于利培酮。

To compare the curative and olanzapine in the treatment of the acute effect and clinical influence factors of risperidone phrase of schizophrenia. METHODS： 27 caseswere treated with risperidone in a regimen of 2-6 mg/d. 26 eases were treated with olanzapine in a regimen of 10-20 mg/d. Positive and Negative Syndrome Scale（PANSS） were used to measure the efficacy for 6 weeks. The patient＇s gender, age, duration before treatment and accurately record the patient＇s drug use were collected dur ing treatment. RESULTS： The response rate at the end of 6 weeks of risperidone and olanzapine both were 84.6%. The general pathological symptoms and positive symptoms, the curative effects of olanzapine is better than those of ris peridone（P%0.05）. Risperidone and olanzapine curative effects in the treatment of the acute phrase of schizophrenia were increased with theextension of the treatment time（P〈0.05）. The treatment time had no interactions with risperi done and olanzapine （P〉 0.05）. Treatment time, duration, dose, affected the efficacy of ris peridone（P〈0.05）, treatment time affected the efficacy of olanzapine （P % 0.05 ）. CONCLU SION. The curative effect between olanzapine and risperidone has no difference,but the stabli ty of olanzapine is better than it of risperidone in the treatment of the acute phrase of schizophre nia.