摘要
目的观察针刺足三里的静息态脑区功能局部一致性（Reho），探讨针刺穴位的作用机制。方法选择10例健康志愿者，其中男性4例，女性6例；年龄20～34岁，中位年龄23岁。利用GESigna HDxt3.0T磁共振成像系统对针刺前（对照组）、针刺足三里后分别进行静息态扫描，运用统计参数图（SPM8）软件，采用Reho的数据后处理方法，分析2组被试不同脑区Reho值的差异.并运用错误发现校正（FDR-corrected），得到有统计学差异的脑区。结果针刺足三里组与针刺前相比，Reho值增高的脑区有右侧前扣带回（8.17）、左侧额中回（4.84）；Reho值减低的脑区有左侧小脑半球（-7.75）、右侧后扣带回（-6.66）、左侧豆状核（-6.87）、右侧岛叶皮层（-7.57）、左侧胼胝体（-5.71）、左侧楔前叶（-4.68）、右侧额叶内侧回（-8.59）。结论针刺足三里后造成局部脑组织血氧水平信号同步性改变，提示针刺足三里不仅有特异的脑功能激活区.而且引起的脑功能活动存在Reho差异。
Objective To explore the mechanism of acupuncture points for regional homogeneity 0Reho） of resting state in brain function after acupuncture at Zusanli（ST36）. Methods Ten healthy volunteers participated were enrolled, which included 4 males and 6 females; aged 20 - 34 years old with median age of 23. The GE Signa HDxt 3.0 T magnetic resonance imaging were performed before（control group） and after acupuncture at Zusanli（ST36）, and differences of different brain Reho between 2 groups by statistical parametric mapping（SPM8） software and Reho data processing methods were analyzed. The statistically different brain regions were obtained by false discovery rate corrected（FDR-corrected）. Results Compared with control group, the right anterior cingulated gyrus（8.17）, left middle frontal gyrus（4.84） were enhanced Reho after acupuncture at Zusanli（ST36）. The left cerebella hemisphere （- 7.75）, right posterior cingulated gyms（- 6.66）, left putamen（- 6.87）, right insular cortex（- 7.57）, left side of corpus callosum（- 5.71）, left precuneus（- 4.68）, right medial frontal（- 8.59） were decreased Reho after acupuncture at Zusanli（ST36）. Conclusion It is demonstrated that the signal synchronization change the oxygen levels of regional brain tissue after acupuncture at Zusanli（ST36）, suggesting that acupuncture Zusanli（ST36） activate specific areas of brain function and Reho differences existed by brain activity after acupuncture at Zusanli（ST36）.
出处
《生物医学工程与临床》
CAS
2014年第2期146-149,共4页
Biomedical Engineering and Clinical Medicine
基金
广东省中医药管理局项目(2010403)
广州中医药大学创新基金项目(09CX033)
