利奈唑胺治疗耐药革兰阳性球菌所致医院获得性肺炎1例

Case report:treatment of hospital-acquired pneumonia caused by Gram-positive bacteria with linezolid

近年来,医院获得性感染中革兰阳性菌感染呈上升趋势,而耐甲氧西林金黄色葡萄球菌(MRSA)已成为医院感染中的常见病原菌,具有多重耐药特征,给临床治疗带来困难。利奈唑胺是第1个应用于临床的新型唑烷酮类抗生素,对葡萄球菌、链球菌、肠球菌等耐药革兰阳性菌有广谱抗菌作用。本文报道1例耐药革兰阳性球菌所致医院获得性肺炎患者,予利奈唑胺治疗后胸部CT示炎症明显吸收,血常规恢复正常,未再发热,病情好转出院。结果显示,利奈唑胺能有效治疗耐药革兰阳性球菌所致医院获得性肺炎。

Recently ,the incidence of hospital-acquired pneumonia associated with Gram-positive bacteria has risen .Methicillin-resistant Staphylococcus aureus （MRSA） has become a major pathogen of nosocomial in-fection ,which is characterized by multi-drug resistance and difficulties in treatment .Linezolid is a new type of oxazolidinone antibiotic used in clinic ,with broad-spectrum antibacterial activity against staphylococci , streptococci ,and enterococci .A patient with hospital-acquired pneumonia caused by Gram-positive cocci was effectively treated by linezolid ,and the procedure and results were reported in this paper .