高危型人乳头瘤病毒基因组整合的研究进展

Research progress on high-risk human papillomavirus integration

高危型人乳头瘤病毒(HPV)基因组整合在宫颈癌等多种肿瘤中被发现。流行病学和实验证据支持高危型HPV基因组整合在宫颈癌等相关肿瘤中起重要作用,其发生可能与宿主染色体不稳定和DNA甲基化相关。近年来发现克隆选择与干扰素通路相关。另外,整合对宿主细胞基因影响和整合位点检测方法方面的研究也取得了重要进展。本文就高危型HPV基因组整合研究的最新进展作一综述。

High-risk human papillomavirus （ HPV ） could integrate into host cell genome in cervical carcinoma .Epidemiological and experimental data support that viral integration plays an important role in cervical carcinogenesis by causing chromosome instability and （or ） DNA methylation . Current studies indicate that interferon pathway may be involved in clone selection .The recent researches on high-risk HPV integration are reviewed .