良恶性淋巴结放疗早期扩散成像与病理相关性研究

Correlation between MRI Diffusion-weighted Imaging and Pathological Features of Benign and Malignant Lymph Node after Radiotherapy

目的:探讨MRI扩散成像监测良恶性淋巴结放疗早期疗效的能力。方法:26只实验兔(转移17只,良性9只)分成A组(转移10只)、B组(转移7只)和C组(良性9只)。A组和C组接受放疗,B组为对照组,分别于放疗前、后第1、3、7天进行常规MR及DWI检查,测量淋巴结的ADC值。三组淋巴结ADC值采用重复测量数据的方差分析。结果:所有实验兔共35个淋巴结,A组16枚,B组10枚及C组9枚。三组ADC值放疗前后变化有明显差异(P﹤0.001),而A组和C组ADC值变化无明显差异(P>0.05)。结论:DWI能够监测良恶性淋巴结放疗后的早期反应,但其区分不同病理特征的能力有局限性。

Purpose： To study the correlation between MRI diffusion-weighted imaging and pathological features of benign and malignant lymph nodes after radiotherapy. Methods： Twenty-six rabbits （metastatic, n=17; benign, n= 9） were divided into group A （metastatic, n= 10）, group B （metastatic, n= 7） and group C （benign, n= 9）. Group A and C underwent radiotherapy, whereas group B was set as reference. Standard MR imaging and DWI were performed before and l, 3, and 7 days after radiotherapy for all rabbits. The lymph node ADCs were measured and evaluated with repeated measures ANOVA. Results： In all rabbits, a total of 35 lymph nodes were found, including 16 nodes in group A, 10 in group B and 9 in group C. A significant difference of variation of ADCs among the three groups was also present （P〈 0.001）. No significant difference of variation of ADCs between group A and C was present. Conclusion： DWI can monitor early radiotherapy response of benign and malignant lymph nodes in animal models. But its capability of differentiating various pathological features is limited.