血管衰老及其机制

Vascular Aging and The Corresponding Mechanisms

血管老化是一个古老而又年轻的课题.本文综述了血管衰老的主要结构特征、功能改变及其机制的新近研究进展,重点就血管基质变化、内皮细胞衰老/功能失调、内皮祖细胞衰竭以及细胞间通讯等方面进行了阐述.

Vascular aging has attracted curiosity and excited imagination throughout the history of humankind. This review focuses on structural and functional changes that occur in the vasculature during aging, as well as the novel founding mechanisms, with special emphasis on extracellular matrix alterations, endothelial progenitor cells endothelial exhaustion, senescence/dysfunction, and altered intercellular communication.