老年人非酒精性脂肪性肝病与良性前列腺增生的关系

Correlation between nonalcoholic fatty liver disease and benign prostatic hyperplasia in elderly men

目的探讨老年人非酒精性脂肪性肝病（NAFLD）与良性前列腺增生（BPH）间的关系。方法选择在我科就诊的老年NAFLD患者50例，以同期就诊的30例无脂肪肝患者作为对照组，比较两组前列腺体积（PV）、体质指数（BMI）、三酰甘油（TG）、空腹血糖（FBG）、空腹胰岛素（FINS）、稳态模型胰岛素抵抗指数（HOMA-IR）等，并将PV与FINS、HOMA-IR等进行相关性分析。结果NAFLD患者PV大于对照组[（48．2±16．3）ml与（33．2±11．5）ml，P〈0．01]，且重度BPH检出率高于对照组[42．O％（21例）与13．3％（4例），P〈0．05]；NAFLD患者BMI、TG、FBG、FINS、HOM～IR均高于对照组（均P〈0．01）；PV与FINS、HOMA-IR水平呈正相关（r值分别为0．814、0．601，均P％0．01）。结论老年人NAFLD与BPH关系密切，可能是BPH危险因素之一。

Objective To investigate the relationship between nonalcoholic fatty liver disease （NAFLD） and benign prostatic hyperplasia （BPH） in elderly patients. Methods 50 elderly BPH men with NAFLD were enrolled in this study, while 30 age-matched BPH men without NAFLD were selected as the control group. Prostate volume （PV）, body mass index （BMI）, triglycerides （TG）, fasting blood glucose （FBG）, fasting plasma insulin （FINS） and homeostasis model of assessment for insulin resistanceindex （HOMA-IR） were compared between the two groups, and correlations of PV with FINS and HOMA-IR were analyzed in the NAFLD patients. Results The PV level was significantly higher in NAFLD patients than in control group [（48.2 ± 16.3） ml vs. （33.2 ± 11.5） ml, P^0. 013. The incidence of severe BPH was higher in NAFLD group than in control group （42.2% w 13.3%, P〈0.05）. BMI, TG, FBG, FINS and HOMA-IR were higher in NAFLD group than in the control group （all P〈0.01）. The PV was positively correlated with FINS and HOMA-IR levels in elderly NAFLD patients （r= 0. 814, 0. 601, respectively, both P〈0.01）. Conclusions NAFLD is closely associated with BPH in elderly males, and NAFLD may be one of the risk factors for BPH.