期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

自噬在肝脏疾病中的作用 被引量：2

Autophagy in liver diseases
下载PDF
导出
摘要 自噬是胞质大分子物质和细胞器在膜包囊泡中降解的生物学过程,具有多种生理功能。近年研究表明,自噬和肝脏疾病的发生、发展有密切关系,预示自噬将成为肝脏疾病研究中的一个新热点。 Autophagy is a process of bulk degradation of care that there is a close relationship between autophagy liver diseases therapy. proteins and organelles in cytoplasm. Recent studies indi- and liver diseases. It provides us a promising avenue for
作者 翁俊华 李娟 徐江海
机构地区 河南省安阳市第五人民医院肝病科
出处 《基础医学与临床》 CSCD 北大核心 2014年第4期559-561,共3页 Basic and Clinical Medicine
关键词 自噬 肝脏疾病 autophagy hepatology
分类号 R575 [医药卫生—消化系统]
  • 相关文献

参考文献20

  • 1Domart MC, Esposti DD, Sebagh M, et al. Concurrent in- duction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemothera- py[J]. Hepatol, 2009, 51:881 -889.
  • 2Zhang C, Cuervo AM. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function[J]. Nat Med, 2008, 14:959 -965.
  • 3Rautou PE, Mansouri A, Lebrec D, et al. Autophagy in liver diseases[ J ]. Hepatol, 2010, 53 : 1123 - 1134.
  • 4Rautou PE, Cazals-Hatem D, Feldmann G, et al. Changes in autophagic response in patients with chronic hepatitis C virus infection[J]. Am J Pathol, 2011, 178:2708-2715.
  • 5Ke PY, Chen SS. Activation of the unfolded protein re- sponse and autophagy after hepatitis C virus infection sup- presses innate antiviral immunity in vitro [ J ]. Clin Invest, 2011, 121: 37-56.
  • 6Sir D, Tian Y, Chen WL, et al. The early autophagic path- way is activated by hepatitis B virus and required for viral DNA replication[J]. Proc Natl Acad Sci USA, 2010, 107: 4383 - 4388.
  • 7Tang H, Da L, Mao Y, et al. Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regu- lation of beclin I expression[ J]. Hepatol, 2009, 49: 60- 71.
  • 8Ni Y, Shi Y, Zhang Y, et al. Effect of autophagy on ex- pression of interferon in hepatitis B virus-infected hepato- cytes[ J]. Wei Sheng Wu Xue Bao 2012, 52:1385 - 1391.
  • 9Yang MC, Chang CP, Lei HY. Endothelial cells are dam- aged by autophagic induction induced acute hepatitis [ J ]. before hepatocytes in Con A- lnt lmmunol, 2010, 22:661 - 670.
  • 10Wang K, Damjanov I, Wan YJ. The protective role of pregnane X receptor in lipopolysaccharide/D-galac- tosamine-induced acute liver injury [ J ]. lab Invest,2010, 90- 257-265.

同被引文献25

  • 1Shuang Ping Guo~1 Wen Liang Wang~1 Yu Qiang Zhai~2 Yi Ling Zhao~1 ~1Department of Pathology,Xijing Hospital of the Fourth Military Medical University,Xi’an,China ~2Department of Urology,the Central Hospital of Xi’an,China.Expression of nuclear factor-KB in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus[J].World Journal of Gastroenterology,2001,7(3):340-344. 被引量：55
  • 2Li Y,Zhang J,Chen X,et al.Molecular machinery of autophagy and its implication in cancer[J].The American journal of the medical sciences,2012,343(2):155-161.
  • 3Vellai T.Autophagy genes and ageing[J].Cell Death Differ,2009,16(1):94-102.
  • 4Tanida I,Ueno T,Kominami E.LC3 conjugation system in mammalian autophagy[J].Int J Biochem Cell Biol,2004,36(12):2503-2518.
  • 5Delarue J,Magnan C.Free fatty acids and insulin resistance[J].Curr Opin Clin Nutr Metab Care,2007,10(2):142-148.
  • 6Inami Y,Yamashina S,Izumi K,et al.Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression[J].Biochem Biophys Res Commun,2011,412(4):618-625.
  • 7Pierre-Emmanuel Rautou,Abdellah Mansour,Lebrec D,et al.Autophagy in liver diseases[J].Journal of Hepatology,2010,53(6):1123-1134.
  • 8Bensaad K,Cheung E C,Vousden K H.Modultion of intracellular Ras levels by TIGAR controls autophagy[J].Embo Journal,2009,28(19):3015-3026.
  • 9陈洁,熊吉,陈潇迪,牟歌,王军,樊丽琳,陈东风.Calpain 2调节自噬相关基因ATG7的表达在非酒精性脂肪性肝病中的作用[J].第三军医大学学报,2011,33(20):2162-2165. 被引量：4
  • 10刘凯,徐树莹,徐斌,陈德喜,李宁.早期自噬在非酒精性脂肪肝中的保护作用[J].北京医学,2011,33(12):947-949. 被引量：14

引证文献2

二级引证文献20

基础医学与临床
2014年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部