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蛋白酶体对血管平滑肌细胞凋亡及表型转换调节作用的研究进展

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摘要 蛋白酶体是广泛存在于真核细胞的一种蛋白复合物，负责降解泛素分子标记的蛋白，为细胞内清除体内异常合成及损坏蛋白的重要机制之一。此外，还通过蛋白合成的转录后调解参与多种重要的细胞功能，如抗原提呈、细胞周期的调节及转录活化因子NF-KB激活等^[1]。近期研究提示蛋白酶体在心血管系统的发育分化中发挥重要作用，同时在动脉粥样硬化、血管损伤后再狭窄、心肌肥大、心肌缺血-再灌注损伤等心血管疾病中发挥重要作用，
作者 李方达 任华亮 郑月宏 李汇华
机构地区 中国医学科学院北京协和医学院血管外科
出处 《中华普通外科杂志》 CSCD 北大核心 2014年第3期235-237,共3页 Chinese Journal of General Surgery
关键词 血管平滑肌细胞凋亡 蛋白酶体 表型转换 调节 心肌缺血-再灌注损伤 转录活化因子 动脉粥样硬化 蛋白合成
分类号 R54 [医药卫生—心血管疾病]
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中华普通外科杂志
2014年 第3期

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