玉溪市老年人与青年人HIV/AIDS免疫状况及死亡情况对比分析

Comparative Analysis on Immune Status and Death Situation Among the HIV/AIDS in Elderly and Youngster in Yuxi Prefecture

目的 通过对玉溪市老年人与青年人HIV／AIDS的免疫状况及死亡情况进行对比分析，为相应防艾策略的制定提供科学依据。方法对2006—2011年间新发现的老年人及青年人HIV／AIDS进行回顾性队列研究．获取CD4^＋T淋巴细胞计数数据，通过艾滋病综合防治信息系统获得HIV／AIDS死亡的相关数据，两组人群进行对比分析。结果老年人HIV／AIDS首次CD4’T淋巴细胞计数小于350cell／μL比例为81．19％，月均CD4^＋T淋巴细胞计数自然变化速率为-7．91cell／μL，1年内病死率14．85％（95％cr：7．90％～21．81％）；青年人分别为38．43％，-1．76cell／μL和4．40％（95％CI：3．30％-5．50％）。两种人群差异均有统计学意义。结论与青年人相比，玉溪市老年人HIV／AIDS被发现的较晚，其CD4^＋T淋巴细胞计数下降速度较快，疾病进展快，导致死亡速度迅猛，必须加快制定针对老年人的HIV防治策略。

Objective To explore the immune status and death situation among the elderly and youngster HIV/AIDS cases in Yuxi prefecture, and to provide the evidence for making relative preventive and therapeutic meas ures. Methods The CD4^＋ T cell counts were collected with retrospective cohort analysis and death situation was collected with follow-up cards during 2006 through 2011 on elderly and youngster,which were statistical- ly analyzed. Results Among the elderly HIV/AIDS, 81.19% primary CD4^＋ T cell counts less than 350cell/ttL,the change of CD4 ＋ T cell counts between the first and the last CD4^＋ T cell counts tests had an average of -7.91 cell/μL in month and the annual mortality rate was 14. 85% （95% CI： 7. 90% ～ 21.81% ）. Among the youngster HIV/AIDS ,38.43% primary CD4^＋ T cell counts less than 350cell/μL. The change of CD4^＋ T cell counts between the first and the last CD4^＋ T cell counts tests had an average of - 1.76cell/μL in month and the annual mortality rate was 4.40% （95% CI：3.30% ～ 5.50% ）. There were statistical significance respectively. Conclusion Compared with youngster, the elderly HIV/AIDS cases were found later and showed significant decreases of CD4^＋ T cell counts, thus a faster disease progression. The elderly were dying at an alarming rate. It was urgent for the management department to work out HIV preven- tion and therapeutic measures.