急性脑梗死患者血清五聚素3与颈动脉粥样硬化斑块相关性研究

Correlation between serum pentraxin 3 and carotid atherosclerosis plaque in patients with acute cerebral infarction

目的探讨急性脑梗死患者血清五聚素3（pentraxin3，PTX3）与颈动脉粥样硬化斑块稳定性的相关性。方法急性脑梗死患者99例（急性脑梗死组）分为无斑块组32例、稳定斑块组34例和不稳定斑块组33例，30例体检健康者为对照组。采用ELISA法检测各组血清PTX3水平并进行比较。结果急性脑梗死组血清PTX3水平明显高于对照组（P〈0．01）；不稳定斑块组血清PTX3水平（（3．19±0．78）μg／L）高于无斑块组（（2．51±1．06）μg／L）及稳定斑块组（（2．68±0．86）μg／L）（P〈0．05），无斑块组与稳定斑块组血清PTX3水平比较差异无统计学意义（P〉0．05）；logistic回归分析显示，PTX3是急性脑梗死患者颈动脉不稳定斑块的独立危险因素（OR=3．23，95％CI：1．29～8．10，P=0．012）。结论急性脑梗死患者血清PTX3水平明显升高，且与颈动脉粥样硬化斑块稳定性密切相关。

Objective To study the correlation between serum pentraxin 3 （PTX3） and the stability of carotid atherosclerosis plaque in patients with acute cerebral infarction （ACI）. Methods Ninety-nine patients with ACI （ACI group） were divided into no-plaques group （n= 32）, stable plaque group （n= 34） and unstable plaque group （n= 33）. Another 30 healthy volunteers were as controls （control group）. The levels of serum PTX3 were measured by ELISA and compared among groups. Results The serum PTX3 level was higher in ACI group than that in control group （P〈0.01）, and higher in unstable plaque group than that in no-plaque group and stable plaque group （P〈 0.05）. There was no significant difference between no-plaque group and stable plaque group （P〉0.05）. Logistic regression analysis revealed PTX3 was an independent risk factor for unstable carotid atherosclerotic plaques （OR= 3.23, 95 %CI： 1.29 to 8.10,P= 0. 012）. Conclusions The serum level of PTX3 increases significantly in patients with ACI, and is closely correlated with the stability of carotid atherosclerotic plaque.