维吾尔族系统性红斑狼疮患者自身抗体特点分析

Feature analysis of autoantibodies in systemic lupus erythematosus in Uygur patients

目的探讨新疆维吾尔族(维族)系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清自身抗体及抗核抗体(antinuclear antibodies,ANA)滴度特征。方法 35例维族SLE患者(维族组)和42例汉族SLE患者(汉族组)采用间接免疫荧光法检测血清ANA阳性率及其滴度,采用免疫印迹法检测抗dsDNA、抗Sm、抗SSA及抗SSB及抗RNP抗体阳性率。结果 2组血清ANA阳性率均为100%;维族组抗dsDNA阳性率(80.0%)高于汉族组(54.8%)(P<0.05);2组抗Sm、抗SSA、抗SSB及抗RNP抗体阳性率比较差异均无统计学意义(P>0.05);维族组ANA滴度>1∶1 000者占88.5%,与汉族组(81.0%)比较差异无统计学意义(P>0.05)。结论维族SLE患者血清自身抗体中ANA最常见,抗dsDNA抗体可做为该人群SLE诊断的血清学指标之一。

Objective To study the distribution and titer characteristics of serum antoantibodies and antinuelear antibodies （ANA） in Uygur patients with systemic lupus erythematosus （SLE）. Methods The positive rate and the titer of serum ANA and anti-dsDNA were detected by indirect immunofluorescence, and the positive rates of anti-dsDNA, anti-Sin, anti-SSA, anti-SSB and anti-RNP were detected by Western blot in 35 Uygur patients and 42 Han patients with SLE. Results The positive rate of serum ANA was 100% in both groups. The positive rate of anti-dsDNA was 80.0% in Uygur patients, significantly higher than that in Han patients （54.8%） （P（0.05）. There were no significant differences in anti-Sm, anti-SSA and anti-RNP between Uygur and Han patients （P〉 0.05）. The proportion of ANA titer 1 ： 1 000 was 88.5% in Uygur patients, showing no significant difference compared with Han patients （81.0%） （P〉0.05）. Conclusions Serum ANA is the most common autoantibody in Uygur SLE patients, and ds-DNA can be used as one of the diagnostic indicators for Uygur SLE patients.