地高辛对心肌梗死后不同程度心功能损伤大鼠生存率的影响

Effect of Digitalis Treatment on the Survival of Myocardial Infavction Rats with Different Cardiac Function

目的:探讨地高辛对心肌梗死后不同程度心功能损伤大鼠生存率的影响。方法:60只Wistar大鼠进行心梗模型建立后被随机分为对照组30例及试验组30例,观察不同心梗面积及不同心功能下地高辛对大鼠生存率的作用。结果:在梗死面积≥37%时,使用地高辛治疗与对照组比较能提高大鼠的存活率(61.3%vs 40%);超声心动图显示FAC≤37%、E/A比值≥3.04、LVDD≥0.82cm、LVSD≥0.62cm及LVSA≥0.26cm2组别中,其280d生存率仍分别维持在60%左右,与对照组的17%-32%的生存率有着显著的提高。结论:地高辛治疗能提高心功能受损程度较严重(心肌梗死面积梗死面积≥37%)心肌梗死后大鼠生存率。

Objective： To explore the effect of digitalis treatment on the survival rate of rats with different cardiac function after myocardial infarction. Methods： The myocardial infarction models were established in 60 Wistar rats, which were divided equally into digoxin treatment group and control group. The 280-day survival rates of rats were analyzed according to different myocardial infarct （MI） size and different heart function. Results： In the rats with MI size≥37%, the digoxin treatment can improve the survival rate from 40% to 61.3%. In the rats with echocardiographic indices such as FAC≤37%, E/A ratio≥3.04 LVDD≥0.82 cm, LVSD≥0.62 cm and LVSA≥0.26 cm^2, the survival rate in digoxin treatment group remained about 60%, which was significantly higher than 17%-32% in control group. Conclusion： Digitalis therapy can improve the survival rate of rats with large area myocardial infarction or with poor cardiac function.