慢性阻塞性肺病急性加重期并发急性冠脉综合征危险因素分析

Risk Factors Analysis of Acute Exacerbation of Chronic Obstructive Pneumonia Disease Accompanied with Acute Coronary Syndrome

目的:探讨慢性阻塞性肺病急性加重期(AECOPD)合并急性冠脉综合征(ACS)的危险因素。方法:回顾性分析149例AECOPD患者临床资料。比较合并ACS患者(A组,33例)及单纯AECOPD患者(B组,116例)在一般情况、既往史、基础疾病、临床症状及实验室资料等方面上的差异。结果:A组年龄较大,肺功能状况更差,有冠心病、高血压、糖尿病既往史者更多;胸痛、双下肢水肿伴发率更高;D-二聚体、炎症标志物、心梗四项值、血糖浓度、丙氨酸氨基转移酶及天冬氨酸氨基转移酶、尿素氮及肌酐值较高,以上差异均有统计学意义(P<0.01或P<0.05)。结论:高龄、肺功能差、冠心病等病史、胸痛等伴发症状,以及凝血、炎症、心梗与肝肾功能指标的升高等,是AECOPD合并ACS的危险因素。

Objective. To investigate the risk factors of acute exacerbation of chronic obstructive pneumonia disease （AECOPD） accompanied with acute coronary syndrome （ACS）. Methods. A total of 149 COPD patients with （n= 33） or without ACS （n= 116） were retrospectively reviewed. Comparative analyses were done on such clinical data as general characteristics, past history, o- riginal disease, clinical symptoms, and clinical tests. Results. As compared with those without ACS, the patients with ACS were older in age,more likely to have poor lung function, original diseases of coronary heart disease, hypertension,and diabetes, and symptoms of chest pain and edema of lower extremity were common,and biochemical indices were higher such as D-dimer, inflammation markers, serum indicators for myocardial infarction, serum glucose, alanine aminotransferase and aspartie acid aminotransferase, urea nitrogen, and serum creatinine value （P〈0.01 or P〈0.05）. Conclusion. Older age,poorer lung function,disease history as coronary heart disease,symptom as chest pain, hyperfunction of coagulation and inflammation,increase of myocardial infarction index, funtion diminishment of liver and kidney,are the risk factors of AECOPD accompanied with ACS.