喉癌组织中Survivin和PTEN基因的表达及其临床意义

Expression of Survivin and PTEN in Laryngeal Carcinoma and Their Clinical Significance

目的:探讨Survivin和PTEN基因在喉癌组织中的表达及其临床意义。方法:采用免疫组织化学法分别检测100例喉癌患者癌变组织中Survivin和PTEN的表达水平,分析其与临床病理特征的关系。结果:PTEN在喉鳞癌中的表达阳性率为41%,阴性率为59%;Survivin在喉鳞癌中的表达阳性率为62%,阴性率为38%。与非喉癌患者的喉黏膜标本相比,两种蛋白的表达率比较差异具有统计学意义(P<0.05)。而且,PTEN和Survivin的表达均分别与肿瘤的进展和增生程度密切相关(P<0.05)。结论:Survivin和PTEN表达水平可作为判断喉癌的重要指标,对临床诊断、治疗及预后判断具有一定的指导意义。

Objective： To detect the expression of survivin and PTEN in laryngeal carcinoma, and investigate their correlation with clinical features. Methods： Immunohistochemistry was used to detect the expression of Survivin and PTEN in cancerous tissue from 100 patients with laryngeal cancer, and then their relationship to the clinical and pathological features were studied. Results： Positive expression rate of PTEN and Survivin was respectively 41% and 62% in laryngeal squamous carcinoma cells, and both were significantly higher than in normal samples （P〈0.05）. Moreover, PTEN and Survivin expression were closely related to the degree of tumor proliferation and progression （P〈0.05）. Conclusion： Survivin and PTEN may be important clinical indicators of laryngeal cancer, and could be useful in the diagnosis, treatment, and progress of laryngeal cancer.