中国汉族癫癇患者中CYP3A41G基因多态性与卡马西平药物浓度的相关性研究

Effect of CYP3A4*1G Genotype on Serum Carbamazepine Concentrations at Steady-state in Han Chinese Epileptic Patients

目的观察CYP3A4*1G基因多态性与中国汉族癫癇患者卡马西平稳态药物浓度的相关性。方法检测177例中国汉族癫癇患者卡马西平单药治疗的稳态药物浓度,采用LDR-PCR测序分型检测CYP3A4*1G基因多态性。结果 CYP3A4*1G基因AA型的卡马西平标准化浓度为(0.23±0.065)μg·mL-1,AG型为(0.25±0.065)μg·mL-1,GG型为(0.28±0.074)μg·mL-1。3种基因型间标准化血药浓度差异有统计学意义(P<0.01),且AA型低于GG型(P<0.01),AG型低于GG型(P<0.05),AA型低于AG型(P<0.01),差异均有统计学意义。结论 CYP3A4*1G基因型影响中国汉族癫癇患者的卡马西平药物浓度,可能是卡马西平药物浓度个体差异的影响因素。

Aim To assess the effect of CYP3A4＊1G genotype on serum carbamazepine （CBZ） concentrations at steady-state.Methods The serum concentrations of CBZ in 177 Han Chinese epileptic patients with CBZ-monotherapy and their CYP3A4＊ 1G genotype was determined by LDR-PCR method.Results Among 177 Han Chinese epileptic patients,the normalized concentrations of CBZ were 0.23 ± 0.065 for CYP3A4＊1G AA allele,（0.25 ± 0.065） μg·mL-1 for AG allele and （0.28 ± 0.074） μg·mL-1 for GG allele.There were a significant differences among these different genotypes （P〈0.01）.The normalized concentrations of CBZ were the highest in GG allele and the lowest in AA allele.Conclusion The CYP3A4＊ 1G genotype may be a factor of affecting the CBZ concentrations in Han Chinese epileptic patients,which contributes to interindividual variability in CBZ disposition.