重症与普通型手足口病患儿入院首次实验室指标比较及意义

Comparison of the laboratory indicators detected for the first time after admission between the patients with ordinary and severe hand, foot and mouth disease

目的分析普通型和重症手足口病(hand,foot and mouth disease,HFMD)患儿入院后首次全面的实验室检查指标,为重症患儿的早期识别提供实验室依据。方法以本院收治的47例普通型和36例重症HFMD患儿(1～4岁)为研究对象,收集入院后首次全面的实验室指标检测结果,用SPSS软件对数据进行统计学分析。结果①重症患儿年龄为1～2岁,多为肠道病毒71型感染;②重症患儿白细胞计数和中性粒细胞百分比的异常率以及血小板计数显著高于普通型患儿;③重症患儿低密度脂蛋白胆固醇水平和异常率都显著高于普通型患儿。结论入院首次全面的实验室检查指标对重症HFMD患儿的早期识别有重要意义,本研究发现血小板计数和低密度脂蛋白胆固醇异常升高在提示重症HFMD发生中的作用。

Objective To analyze the laboratory indicators detected for the first time after admission between the patients with ordinary and severe hand, foot and mouth disease （HFMD）, and provide laboratory evidence for early identification of severe HFMD patients. Methods Forty-seven ordinary HFMD patients and 36 severe HFMD patients （1-4 years old） were enrolled in the study. The laboratory indicators detected for the first time after admission were collected and analyzed by SPSS statistical software. Results The severe HFMD children were 1-2 years old, and the majority of them were infected by human enterovirus 71. The pro-portions of severe HFMD children with abnormal white blood cell count and neutrophil percentage, and PLT level of severe HFMD children were significantly higher than those of ordinary HFMD children. The level of low density lipoprotein cholesterols （LDL-C） and its abnormality in severe HFMD children were significantly higher than those in ordinary HFMD children. Conclusions The laboratory indicators detected for the first time after admission is of great importance in early identification of severe HFMD patients. This study identifies the role of abnormally elevated level of PLT and LDL-C in suggesting the occurrence of severe HFMD.