流行性腮腺炎合并睾丸炎的血清细胞因子水平分析

Serum cytokine levels of patients with mumps orchitis

目的观察流行性腮腺炎合并急性睾丸炎患者的血清细胞因子水平变化。方法入选2012年1月—2013年5月在我院感染科住院治疗的流行性腮腺炎合并急性睾丸炎患者30例(合并睾丸炎组),同时选择无主要并发症的单纯性流行性腮腺炎30例(单纯腮腺炎组)。检测2组患者血清白细胞介素(interleukin,IL)-2、IL-4、IL-6、IL-8、IL-10、干扰素γ和肿瘤坏死因子(tumor necrosis factor,TNF)-α的水平。结果合并睾丸炎组患者血清IL-6和TNF-α水平[(6.7±3.5)pg/ml、(43.1±28.2)ng/ml]高于单纯腮腺炎组[(3.2±1.5)pg/ml、(32.5±21.1)ng/ml],2组比较差异有统计学意义。结论腮腺炎病毒感染后血清IL-6和TNF-α高水平可能是参与诱发睾丸炎的始动因素。

Objective To investigate serum cytokine levels of patients with acute mumps orchitis. Methods Thirty patients with acute mumps orchitis （mumps orchitis group） and 30 patients with mumps only without any major complications （mumps group）, who were treated in infectious diseases department of our hospital from Jan. 2012 to May 2013, were enrolled in the study. Serum levels of interleukin （IL）-2, IL-4, IL-6, IL-8, IL-10, interferon γand tumor necrosis factor （TNF）-α of the two groups were tested. Results The levels of IL-6 and TNF-αof mumps orchitis group （6.7±3.5 pg/ml, 43.1±28.2 ng/ml） were higher than those of mumps group （3.2±1.5 pg/ml, 32.5±21.1 ng/ml）, and the differences were significant between the two groups. Conclusion High serum levels of IL-6 and TNF-αmay be the trigger factors of orchitis in patients with mumps.