摘要
目的:探讨长方案中长效与短效达菲林的垂体降调节效果及体外受精-胚胎移植的妊娠结局.方法行体外受精助孕的患者317例,均于前1月经周期黄体中期开始注射达菲林.随机分为2组,A组(145例)皮下注射长效达菲林1.25 mg,单次给药;B组(172例)每天皮下注射短效达菲林0.1 mg,14-18 d降调节后减量至每天注射0.05 mg,直到HCG注射日.结果(1)促性腺激素使用天数及用量:A组[(11.8±2.1) d,(31.2±9.5)支]显著多于B组[(10.1±1.3) d,(25.4±9.3)支],P〈0.05;(2)2组患者的获卵数、受精率、优质胚胎数、着床率比较差异无统计学意义(P〈0.05);(3)临床妊娠率:2组比较差异无统计学意义(P〈0.05),但B组有增高趋势.结论长方案中短效达菲林的垂体降调节效果与长效达菲林相似,而促性腺激素用量更少,使用更灵活,值得推荐.
Objective To explore the efficacy of long- and short-acting triptorelin on pituitary down-regulation in long protocol and the pregnancy outcome in vitro fertilization and embryo transfer (IVF-ET) . Methods Three hundred and seventeen patients for IVF-ET were enrolled as study and randomized them into two groups. In group A (n=145), patients received single dose subcutaneous injection of 1.25 mg long-acting diphereline in mid-luteal phase. In group B (n=172), patients received 0.1 mg/d subcutaneous injection of short-acting diphereline in mid-luteal phase for 14-18 days until pituitary suppression were got,and then reduced to 0.05 mg/d until the injection of HCG. Results The dose and the days of gonadotropin administration in group A were bigger and longer than those in group B ( P〈0.05) . There were no significant differences in the number of retrieved oocytes, fertilization rate,high quality embryos,implantation rate and clinical pregnancy rate between the two groups (all P〈 0.05) . But clinical pregnancy rate of group B had increasing trend. Conclusion Administration of short-acting diphereline has the similar effect with that of long-acting diphereline on pituitary down-regulation in long protocol. Short-acting diphereline requires lower amount of gonadotropin and is more flexible,so it should be recommended.
出处
《昆明医科大学学报》
CAS
2014年第2期63-66,共4页
Journal of Kunming Medical University
基金
云南省卫生厅内设机构研究基金资助项目(2010NS054)
关键词
达菲林
垂体降调节
体外受精
Diphereline
Pituitary down-regulation
In vitro fertilization