慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系研究

Correlation of Serum Lipoxin A4 with Clinical Grading of Chronic Hepatitis B Patients

目的探讨慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系.方法选取病毒性肝炎乙型慢性轻度患者34例、慢性中度患者30例,慢性重度患者30例,采集患者外周静脉血分离血浆,应用酶联免疫方法测定血浆脂氧素A4的含量,分析脂氧素A4与慢性乙型肝炎临床分度的关系.结果慢性重度肝炎患者外周血脂氧素A4水平显著低于慢性轻度患者和慢性中度患者(P<0.05),和疾病临床分度显著相关.外周血血浆脂氧素A4的含量与ALT和AST的水平均成负相关,相关系数为分别为r=-0.41,P=0.019和r=-0.37,P=0.034.结论外周血血浆脂氧素A4的含量与慢性乙型肝炎临床分度相关.

Objective To explore the correlation between serum Lipoxin A4 and clinical grading of chronic hepatitis B patients. Method The serum Lipoxin A4 was detected by Enzyme-Linked Immunosorbent Assay in 94 chronic hepatitis B patients. Results It was found that the level of serum Lipoxin A4 of severe hepatitis patients were significantly lower than mild hepatitis patients and moderate hepatitis patients （ =0.04 and =0.03） . The serum Lipoxin A4 levels were correlated negatively with the ALT and AST levels,respectively =-0.41, =0.019 and R=-0.37,P=0.034. Conclusion These findings support the fact that the serum Lipoxin A4 may contribute to clinical grading of chronic hepatitis B patients.