血清淀粉样蛋白A与类风湿关节炎疾病活动度的相关性研究

The Correlation between Serum Amyloid A and Disease Activity in Patients with Rheumatoid Arthritis

目的探讨血清淀粉样蛋白A(SAA)与类风湿关节炎(RA)疾病活动度的相关性及临床意义。方法收集44例RA患者、35例系统性红斑狼疮(SLE)患者、18例骨关节炎(OA)患者及30例正常对照者血清。采用酶联免疫吸附试验(ELISA)定量检测血清中SAA的浓度;魏氏法检测红细胞沉降率(ESR);免疫比浊法检测C反应蛋白(CRP)的浓度。将血清SAA水平与疾病活动度评分(DAS28)及ESR、CRP等进行相关分析。结果 RA患者血清中SAA的水平均高于其他3组(P<0.05),血清ESR和CRP的浓度分别高于OA和正常对照组,与SLE组相比差异无统计学意义(P>0.05)。血清SAA水平分别与DAS28、ESR及CRP水平呈正相关,rs分别为0.790、0.674和0.679(均P<0.001)。结论 SAA可作为评估RA疾病活动度的新的血清学指标。

Objective To investigate the correlation between serum amyloid A （SAA） and disease activity （DAS28） in patients with rheumatoid arthritis （RA）. Methods Forty-four patients with RA, 35 patients with systemic lupus erythe-matosus （SLE）, 18 patients with osteoarthritis （OA） and 30 healthy controls （HC） were enrolled in this study. The levels of SAA were measured by ELISA. Erythrocyte sedimentation rate （ESR） was measured by the Westergren method. The value of serum C reactive protein （CRP） was examined by immunonephelometry assay. The correlation between SAA and DAS 28, ESR and CRP was assessed, respectively. Results The SAA levels were significantly higher in RA group than those of SLE, OA, and HC groups （P＆lt;0.05）. The serum ESR and CRP levels were both higher in RA group than those of OA and HC groups （P＆gt;0.05）, but there was no significant difference between RA group and SLE group. There was positive correlation between SAA and DAS28, ESR, and CRP levels （rs=0.790, P＆lt;0.001;rs=0.674, P＆lt;0.001;rs=0.679, P=0.004）, respective-ly. Conclusion SAA may be a new serological marker to assess disease activity in RA.