血清降钙素原在急性发热疾病诊断中的价值

The Diagnostic Value of Procalcitonin in Patients with Acute Febrile Disease

目的:探讨血清降钙素原在急性发热疾病诊断中的价值。方法:研究对象为急性发热患者87例,其中细菌感染组49例,病毒感染组38例,另选正常对照组35例,通过检测三组血清降钙素原水平,对比各组患者治疗前血清降钙素原水平,并检测使用抗生素3-5天后患者血清中降钙素原水平。结果:治疗前细菌感染组患者血清降钙素原水平显著高于病毒感染组和正常对照组(P均<0.05),病毒感染组与正常对照组血清降钙素原无统计学差异(P=0.075);细菌感染组在抗生素治疗3-5天后血清降钙素原水平显著低于治疗前水平(P<0.001)。结论:降钙素原的检测对急性发热患者病因诊断有一定的临床价值,并能评估细菌感染的治疗预后。

Objective： To investigate the diagnostic value of procalcitonin in patients with acute febrile disease. Methods：We recruited 87 patients with acute febrile disease including 49 patients with confirmed diagnosis of bacterial infection and 38 patients with virus infection. In addition, 35 healthy volunteers were included. Serum procalcitonin was detected in all the subjects. The serum procalcitonin was compared among the three groups. The levels of procalcitonin in bacterial infection group were also evaluated after 3-5 days antibiotic treatment. Results： The level of procalcitonin in patients with bacterial infection was significantly higher than that in virus infection group and the control group （all P 〈 0.05）.There was no significant difference between the virus infection group and the control group （P = 0.075）. After 3-5 days antibiotic treatment, the levels of procalcitonin in bacterial infection group was decreased significantly （P 〈 0.001 ）. Conclusions： Serum procalcitonin has a certain value in the differential diagnosis of acute febrile disease and predicts the prognosis and treatment.