妊娠晚期孕妇阴道B族链球菌带菌状况与早产的相关性研究

The Relationship between Status of Vagina Group B Streptococcal Colonization of Pregnant Women in the Third Trimester and Premature Birth

目的:探讨妊娠晚期孕妇B族链球菌(GBS)带菌状况与早产关系。方法:以2012年1月-2013年1月我院产科出生的部分早产儿147例为早产组,以同期出生的足月儿作为足月组,按照性别比例1:1配对进行病例对照研究。比较所有研究对象产科临床资料和孕妇宫颈分泌物GBS培养结果。结果:早产组孕妇GBS感染携带率为28.5%(42/147),足月组孕妇GBS感染携带率仅为11.5%(17/147),早产组GBS携带率显著高于足月组(P<0.05)。因素配比条件Logistic回归分析显示,反复流产、多/双胎病史、胎膜早破、产前出血、子痫前期、胎儿窘迫及孕妇GBS带菌均为早产独立危险因素,P均<0.05,其中孕妇GBS带菌的OR值为2.073(95%CI:1.774-4.706)。结论:妊娠期GBS携带孕母早产的发生率较GBS非携带明显升高。

Objective：To explore the relationship between status of vagina group streptococcal （GBS） colonization of pregnant women in the third trimester and premature birth. Method：A case-control study was performed in 147 premature neonates matched with other 147 full term neonates by sex as the control group. The risk factors for premature birth were collected by questionnaire from Jan 2012 to Jan 2013. Cervical secretions of pregnant women were collected for GBS culture. The clinical data and the results of GBS culture were analyzed. Result： The rate of pregnant GBS contamination in premature group was significantly higher than that in the full term group （28.5% vs 11.5% ,P〈0.05）.Conditional matched logistic regression analysis showed that recurrent miscarriage, multi/twin history, premature rupture of membranes, antepartum hemorrhage, preeclampsia, fetal distress and pregnant GBS colonization were independent risk factors for premature birth （P〈0.05）, and the OR value for pregnant GBS colonization was 2.073 （95% CI：1.774-4.706）. Conclusion： The incident rate of premature birth in pregnant women with GBS colonization increased compared with pregnant women without GBS colonization.