老老年骨质疏松症与心血管病危险因素的相关性回顾

Correlational analysis of osteoporosis and the risk factors of cardiovascular diseases in the elderly

目的探讨老老年患者骨质疏松症与心血管疾病危险因素的相关性。方法选取2008年1月至2012年7月广州市第一人民医院老年病科住院的≥75岁的患者1073例,根据骨密度结果分为骨质疏松组及骨量正常组,并记录其合并的心血管疾病情况及危险因素。结果骨质疏松组中,冠心病、高血脂、糖尿病及吸烟所占的比例高于骨量正常组,两组比较差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,同型半胱氨酸、低密度脂蛋白、胆固醇为老年骨质疏松患者的主要危险因素,HDL、体重为老年骨质疏松患者的保护因素。女性、高血压、冠心病、高脂血症、糖尿病均为老年骨质疏松主要危险合并症。结论老老年骨质疏松症是一个全身性疾病,与冠心病、高脂血症等心血管疾病及危险因素密切相关,应全面治疗及预防。

Objective To study the correlation between osteoporosis and the risk factors of cardiovascular diseases in the elderly. Methods One thousand and seventy-three patients, who were hospitalized in the Department of Geriatrics in Guangzhou First People＇s Hospital, from January 2008 to July 2012, with the age over 75 years old, were selected. All the patients were divided into osteoporosis group and normal bone mass group according to their bone mineral density. The combined cardiovascular diseases and the related risk factors were recorded. Results The proportion of patients with coronary heart diseases, hyperlipidemia, diabetic mellitus, and smoking in osteoporosis group was significantly higher than that in normal bone mass group （P 〈 0.05 ）. Multivariate logistic regression analysis showed that HCY, LDL, and TC were the major risk factors of osteoporosis in the elderly. HDL and body weight were protective factors. Female, hypertension, coronary heart diseases, hyperlipidemia, and diabetes mellitus were the main risk factors of complication in the elderly patients with osteoporosis. Conclusion Senile osteoporosis is a systematic disease, which is closely correlated with cardiovascular disease-related risk factors including coronary heart disease and hyperlipidemia, and should be treated and prevented comprehensively.