动脉自旋标记与动态对比增强MRI脊柱骨髓灌注成像对照研究

A comparative study of arterial spin labeling and dynamic contrast-enhanced MRI of spinal bone marrow perfusion imaging

目的:分析动脉自旋标记(ASL)与动态对比增强MRI(DCE-MRI)脊柱骨髓灌注成像参数间的相关性,探讨ASL测量脊柱骨髓血流灌注的可行性。方法:对27位志愿者的54个腰椎椎体行ASL及DCE-MRI扫描,将原始图像传入GE AW 4.4工作站分别采用Functool及Cine tool软件进行后处理,每个椎体用一个兴趣区(ROI)覆盖,记录椎体骨髓的ASL灌注血流量(BFASL)及DCE-MRI灌注参数(Ktrans、Kep、Ve),并用Pearson法分析BFASL与Ktrans、Kep、Ve间的相关性。结果:腰椎脊髓灌注的BFASL与Ktrans、Kep正相关,r值分别为0.646(P<0.001)、0.387(P=0.004),与Ve值无相关性,r=0.239(P=0.082)。结论:用ASL法可以得到脊柱骨髓灌注BFASL值,而且BFASL与DCE-MRI脊柱骨髓灌注参数间存在相关性,ASL技术有评估腰椎骨髓血流灌注的潜能。

Objective：To analyse the correlation between arterial spin-labeling （ASL） and dynamic contrast-enhanced magnetic resonance imaging （DCE-MRI） in the measurement of spinal bone marrow （SBM） perfusion,in order to explore the feasibility of ASL in the measurement of SBM blood flow. Methods： ASL and DCE-MRI was performed on 54 lumbar vertebral bodies from 27 subjects. Each vertebral body was covered by one region of interest （ROI） and the original images were all reprocessed with Functool and Cinetool at AW 4.4 workstation, respectively. The correlation between the blood flow on ASL （BFAsL） and perfusion-related parameters （K , Kep, Ve ） on DCE-MRI were evaluated using the Pearson cor relation coefficient. Results：Blood flow on ASL （BFAsL） showed a close correlation with K （r= 0. 646,P=0. 001） and Kep （r= 0. 387, P = 0. 004）, but showed no correlation with Ve （ r = 0. 239, P = 0. 082）. Conclusion： As blood flow measurement on ASL is reliable and closely related with the parameters on DCE-MR,ASL is feasible for measuring SBM blood flow.