急性脑梗死患者外周血CD4CD25 T细胞和CD4CD28^- T细胞的变化

Changes of peripheral CD4CD25 and CD4CD28^- T cells in acute cerebral infarction patients

目的探讨急性脑梗死患者外周血CD4CD25T细胞和CD4CD28-T细胞亚群的变化及意义。方法选择急性脑梗死患者22例(脑梗死组),另选取健康体检者18例(对照组);均采用流式细胞仪检测外周血CD4CD25T细胞和CD4CD28-T细胞占CD4T细胞比例。结果脑梗死组外周血CD4CD25T细胞/CD4T细胞比例明显低于对照组[(41.14±9.92)%vs(49.01±12.19)%,P<0.05],而CD4CD28-T细胞/CD4T细胞比例明显高于对照组[(19.93±15.60)%vs(11.96±8.60)%,P<0.05]。结论急性脑梗死患者外周血CD4CD25T细胞比例减少,而CD4CD28-T细胞升高,两者共同作用,可能在脑梗死发生、发展中起重要作用。调节T淋巴细胞亚群可能是脑梗死的潜在治疗靶点。

Objective To study the changes of peripheral CD4CD25 and CD4CD28-T cells in acute cerebral infarction （ACI） patients.Methods Twenty-two ACI patients served as an ACI group and 18 healthy volunteers served as a control group in this study.The ratio of peripheral CD4CD25/CD4 T cells and CD4CD28-T cells/CD4 T cells was assayed by flow cytometry.Results The ratio of CD4CD25 T cells/CD4 T cells was significantly lower in ACI group than in control group while that of CD4CD28-T cells/CD4 T cells was significantly higher in ACI group than in control group （41.14%±9.92% vs 49.01%±12.19%,P〈0.05;19.93%±15.60% vs 11.96 %±8.60 %,P〈0.05）.Conclusion The ratio of peripheral CD4CD25 T cells is lower and that of CD4CD28-T cells is higher in ACI patients.CD4CD25 and CD4CD28-T cells play an important role in the developmant and progression of ACI.Regulating T lymphocyte subgroup may be a potential treatment target of cerebral infarction.