冠状动脉狭窄程度与冠心病危险因素的相关性分析

Correlation between coronary artery stenosis and risk factors for coronary heart disease

目的探讨冠状动脉狭窄程度与冠心病危险因素的相关性。方法连续性收集我科行冠状动脉造影的患者121例,根据造影结果,将患者分为冠心病组89例与对照组32例。收集2组患者临床、实验室和影像学资料,采用单因素和多因素logistic回归模型进行分析。结果冠心病组男性、糖尿病、吸烟比例和LDL-C水平均高于对照组,HDL-C水平低于对照组(P<0.05);多因素logistic回归分析示,糖尿病(OR=3.769,P=0.042)、LDL-C水平(OR=1.873,P=0.021)是冠心病的独立危险因素。中、重度冠状动脉狭窄患者吸烟比例均高于轻度狭窄者,中度狭窄患者男性比例、年龄与尿酸水平和重度狭窄患者高血压、糖尿病比例均高于轻度狭窄者,差异均有统计学意义(P<0.05);logistic回归分析示,年龄(OR=1.094,P=0.001)、高血压(OR=3.340,P=0.003)、糖尿病(OR=3.877,P=0.003)和吸烟(OR=4.536,P=0.003)与冠状动脉狭窄程度相关。结论冠心病的危险因素与冠状动脉狭窄程度存在显著相关性,其中糖尿病是两者共同的重要危险因素。

Objective To study the correlation between coronary artery stenosis and risk factors for coronary heart disease （CHD）.Methods One hundred and twenty-one patients were divided into CHD group （n=89） and control group （n=32） according to their coronary angiography.Their clinical,laboratory and imaging data were analyzed by univariate and multivariate logistic regression analysis.Results The proportions of males,diabetes and smokers,and LDL-C level were significantly higher while the HDL-C level was significantly lower in CHD group than in control group （P〈0.05）.Multivariate logistic regression analysis showed that diabetes and LDL-C level were the independent risk factors for CHD （OR =3.769,P =0.042 ; OR =1.873,P =0.021）.The number of smokers was greater in moderate and severe coronary artery stenosis patients than in mild coronary artery stenosis patients.Th number of male patients,age and uric acid level in moderate coronary artery stenosis patients and the incidence of hypertension and diabetes in severe coronary artery stenosis patients were significantly higher than those in mild coronary artery stenosis patients （P〈0.05）.Logistic regression analysis showed that age,hypertension,diabetes and smoking were the risk factors for coronary artery stenosis （OR=1.094,P=0.001;OR=3.340,P=0.003;OR=3.877,P=0.003;OR=4.536,P=0.003）.Conclusion Risk factors for CHD are closely related with coronary artery stenosis.Diabetes is an important risk factor for both CHD and coronary artery stenosis.