血清CRP和TC/HDL-C的联合检测与糖尿病并发心血管疾病的相关性研究

The correlation studies between Serum CRP and TC/HDL-C and diabetes complicated with cardiovascular disease

目的探讨血清C反应蛋白(CRP)和胆固醇(TC)/高密度脂蛋白C(HDL-C)的联合检测与糖尿病并发心血管疾病的相关性。方法以糖尿病(DM)组(n=36),糖尿病并发心血管病(DH)组(n=33)和健康对照组(n=32)空腹血清标本为本研究试验样品,分别测定各组CRP、TC、FBG、HDL-C的水平并比较试验组和对照组之间的差异。结果各糖尿病组CRP、TC/HDL-C、FBG含量显著高于对照组,差别有显著性(P<0.01);糖尿病并发心血管病组CRP、TC/HDL-C、FBG含量显著高于糖尿病组,差别有显著性(P<0.01)。CRP和TC/HDL-C、FBG之间呈显著正相关(r分别是0.221和0.165,P<0.01);CRP与HDL-C之间呈显著负相关(r=-0.116,P<0.05)。结论 CRP和TC/HDL-C是反映糖尿病并发心血管病情严重程度的敏感指标,密切监测患者CRP和TC/HDL-C的变化情况,可以为临床诊断、治疗和预测糖尿病并发心血管疾病提供可靠的依据。

Objective To investigate the correlation between serum C-reactive protein（ CRP） and cholesterol（ TC） / high-density lipoproteinC（ HDL-C） and diabetes complicated with cardiovascular disease. Methods Serum samples were collected from patients in diabetes mellitus（ DM） group（ n = 36） and diabetes complicated with cardiovascular disease（ DH） group（ n = 33） and healthy controls（ n = 32）,the levels of TC, FBG and HDL-C in serum were testedand the differences between experimental group and control group were compared. Results CRP,TC / HDL-C and FBG concentration in diabetes groupswere significantly higher than thosein control group（ P 0. 01）; CRP,TC / HDL-C and FBG levels in Diabetes mellitus complicated with cardiovascular disease group were significantly higher than those in diabetes group,the differenceswerestatistically significant（ P 0. 01）. Level of CRP was positively correlated to TC / HDL-C and FBG level（ r were 0. 221 and 0. 165respectively,P 0. 01）,and negatively correlated to HDL-C level（ r = 0. 116,P 0. 05）. Conclusions CRP and TC / HDL-C concentration in serum were sensitive index for judging the severity of diabetes complicated with cardiovascular disease.