摘要
目的探讨血清C反应蛋白(CRP)和胆固醇(TC)/高密度脂蛋白C(HDL-C)的联合检测与糖尿病并发心血管疾病的相关性。方法以糖尿病(DM)组(n=36),糖尿病并发心血管病(DH)组(n=33)和健康对照组(n=32)空腹血清标本为本研究试验样品,分别测定各组CRP、TC、FBG、HDL-C的水平并比较试验组和对照组之间的差异。结果各糖尿病组CRP、TC/HDL-C、FBG含量显著高于对照组,差别有显著性(P<0.01);糖尿病并发心血管病组CRP、TC/HDL-C、FBG含量显著高于糖尿病组,差别有显著性(P<0.01)。CRP和TC/HDL-C、FBG之间呈显著正相关(r分别是0.221和0.165,P<0.01);CRP与HDL-C之间呈显著负相关(r=-0.116,P<0.05)。结论 CRP和TC/HDL-C是反映糖尿病并发心血管病情严重程度的敏感指标,密切监测患者CRP和TC/HDL-C的变化情况,可以为临床诊断、治疗和预测糖尿病并发心血管疾病提供可靠的依据。
Objective To investigate the correlation between serum C-reactive protein( CRP) and cholesterol( TC) / high-density lipoproteinC( HDL-C) and diabetes complicated with cardiovascular disease. Methods Serum samples were collected from patients in diabetes mellitus( DM) group( n = 36) and diabetes complicated with cardiovascular disease( DH) group( n = 33) and healthy controls( n = 32),the levels of TC, FBG and HDL-C in serum were testedand the differences between experimental group and control group were compared. Results CRP,TC / HDL-C and FBG concentration in diabetes groupswere significantly higher than thosein control group( P 0. 01); CRP,TC / HDL-C and FBG levels in Diabetes mellitus complicated with cardiovascular disease group were significantly higher than those in diabetes group,the differenceswerestatistically significant( P 0. 01). Level of CRP was positively correlated to TC / HDL-C and FBG level( r were 0. 221 and 0. 165respectively,P 0. 01),and negatively correlated to HDL-C level( r = 0. 116,P 0. 05). Conclusions CRP and TC / HDL-C concentration in serum were sensitive index for judging the severity of diabetes complicated with cardiovascular disease.
出处
《齐齐哈尔医学院学报》
2014年第3期318-319,共2页
Journal of Qiqihar Medical University