期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

RUNX3基因与胃癌的研究进展 被引量：1

The Research Progress of Gene RUNX3 and Gastric Cancer
下载PDF
导出
摘要 Runt相关转录因子3(RUNX3)基因在胃癌中被发现以来便以抑癌基因的身份被国内外众多学者所关注,认为其可能是胃癌发生、发展相关基因中的关键性基因,此后在其他多种恶性肿瘤中也均有发现。并且,在多种肿瘤中RUNX3基因高甲基化能使其表达失活,尤其与胃癌的发生密切相关。去甲基化能使沉默的RUNX3重新表达恢复抑制肿瘤发生的功能。RUNX3基因为胃癌未来靶向治疗提供了一种新思路。 Since the gene RUNX3 was found as a tumor suppressor in gastric cancer, many domestic and foreign scholars became concerned that it might be one of the key factors of gastric cancer＇s development, which was also found in other malignant tumors recently. Studies have shown that hypermethylation of RUNX3 could inactivate the expression, which is especially closely related with gastric cancer. It was also believed that the demethylation would be able to re-express of silent RUNX3 and recover the function of tumor inhibition. The RUNX3 gene provide a new idea in the gastric cancer＇s future targeted therapy for the clinicians.
作者 刘宇辉 许岸高
机构地区 广东医学院
出处 《医学综述》 2014年第4期640-642,共3页 Medical Recapitulate
关键词 RUNT相关转录因子3 胃癌 甲基化 Runt-related transcription factor 3 Gastric cancer Methylation
分类号 R73 [医药卫生—肿瘤]
  • 相关文献

参考文献22

  • 1Wanajo A,Sasaki A,Nagasaki H,et al.Methylation of the calcium channel-related gene,CACNA2D3,is frequent and a poor prognostic factor in gastric cancer[J] .Gastroenterology,2008,135(2):580-590.
  • 2Li QL,Ito K,Sakakura C,et al.Causal relationship between the loss of RUNX3 expression and gastric cancer[J] .Cell,2002,109(1):113-124.
  • 3Bangsow C,Rubins N,Glusman G,et al.The RUNX3 gene-sequence,structure and regulated expression[J] .Gene,2001,279(2):221-232.
  • 4Coffman JA.Runx transcription factors and the developmental balance between cell proliferation and differentiation[J] .Cell Biol Int,2003,27(4):315-324.
  • 5Tang YY,Shi J,Zhang L,et al.Energetic and functional contribution of residues in the core binding factor beta (CBFbeta) subunit to heterodimerization with CBFalpha[J] .J Biol Chem,2000,275(50):39579-39588.
  • 6Tahirov TH,Inoue-Bungo T,Morii H,et al.Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta[J] .Cell,2001,104(5):755-767.
  • 7Bae SC,Choi JK.Tumor suppressor activity of RUNX3[J] .Oncogene,2004,23(24):4336-4340.
  • 8Ito K,Lim AC,Salto-Tellez M,et al.RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis[J] .Cancer Cell,2008,14(3):226-237.
  • 9Esteller M.Epigenetics in cancer[J] .N Engl J Med,2008,358(11):1148-1159.
  • 10Chan SL,Cui Y,van Hasselt A,et al.The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas[J] .Lab Invest,2007,87(7):644-650.

二级参考文献12

  • 1王丽江,甘润良,黄幼生,周建国,龚邵新.应用自制微切割工具切割石蜡组织行PCR-银染[J].诊断病理学杂志,2004,11(5):360-361. 被引量：4
  • 2马琳,张军航,刘芙蓉,张学.卵巢上皮性恶性肿瘤组织RASSF1A基因启动子区甲基化的研究[J].中华肿瘤杂志,2005,27(11):657-659. 被引量：8
  • 3田筱青,张军,范立宏,郭长存.上消化道癌肿中runx3基因甲基化研究[J].中华消化杂志,2005,25(11):688-689. 被引量：7
  • 4Gen Tamura.Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer[J].World Journal of Gastroenterology,2006,12(2):192-198. 被引量：107
  • 5Li QL, Ito K, Sakakura C, Fukamachi H, lnoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Hart SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002; 109:113-124.
  • 6Bangsow C, Rubins N, Glusman G, Bernstein Y,Negreanu V, Goldenberg D, Lotem J, Ben-Asher E, Lancet D, Levanon D, Groner Y. The RUNX3 gene-- sequence, structure and regulated expression. Gene 2001; 279:221-232.
  • 7Bae SC, Choi JK. Tumor suppressor activity of RUNX3. Oncogene 2004; 23:43364340.
  • 8Ito Y. Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF. Genes Cells 1999; 4: 685-696.
  • 9Nam S, Jin YH, Li QL, Lee KY, Jeong GB, Ito Y, Lee J, Bae SC. Expression pattern, regulation, and biological role of runt domain transcription factor, run, in Caenorhabditis elegans. Mol Cell Biol 2002; 22:547-554.
  • 10Ito Y, Miyazono K. RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr Opin Genet Dev 2003; 13:43-47.

共引文献25

同被引文献14

  • 1Miyazono K,Maeda S,Imamura T.Coordinate regulation of cell growth and differentiation by TGF-βsuper family and Runx Proteins[J].Oncongene,2004,23(24):4232-4237.
  • 2Watanabe T,Kobunai T,Ikeuchi H,et al.RUNX3 copy number predicts the development of UC.associated colorectal cancer[J].Int J Oncol,2011,38(1):201-207.
  • 3Kodach LL,Jacobs RJ,Heijmans J,et al.The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3in colorectal cancer[J].Carcinogenesis,2010,31(9):1567-1575.
  • 4Li QL,Ito K,Sakakura C,et al.Causal relationship between the loss of RUNX3 expression and gastric cancer[J]].Cell,2002,109(1):113-124.
  • 5Deng T,Zhang Y.5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in eolorectal cancer Lovo cells[J].Biomed Pharmacother,2009,63(7):492-500.
  • 6Daniel P,Wagrowska-Danilewcz M,Danilewicz M,et al.TGF-β1and MMP-9 over expression in colorectal cancer(CC)and adenoma[J].Int J Colorectal Dis,2007,22(10):1165-1172.
  • 7Vogelmann R,Nguyen-Tat MD,Giehl K,et al.TGF beta-induced down regulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN[J].Cell Sci,2005,118(Pt 20):4901-4912.
  • 8Tong D,Qu H,Meng X,et al.S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-βsignaling pathway in cancer cells[J].Oncol Rep,2014,32(3):1124-1132.
  • 9李晓勇,刘少平.结直肠癌患者血清TGF-β1的检测及临床意义[J].广西医科大学学报,2011,28(1):82-84. 被引量：11
  • 10何绍亚,韩盛玺,蒋仁发,向阳生.Runx3基因甲基化及Runx3蛋白表达在结肠癌发生中的意义[J].世界华人消化杂志,2011,19(17):1860-1863. 被引量：10

引证文献1

二级引证文献4

医学综述
2014年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部