多形胶质母细胞瘤的综合治疗进展

The Advances in the Multidiscipline Modality Treatment of Glioblastoma Multiforme

多形胶质母细胞瘤是颅内最常见的恶性肿瘤之一,治疗疗效差。近年来,脑多形胶质母细胞瘤的综合治疗的进展主要体现在替莫唑胺同步放化疗+辅助化疗的治疗以及联合分子靶向治疗的应用。尽管目前表皮生长因子受体抑制剂未能提高多形胶质母细胞瘤的疗效,但其他的分子靶向治疗药物,如血管内皮生长因子受体抑制剂正在进行临床研究,期望能够进一步提高疗效。

Glioblastoma multiforme is one of the most common malignant brain tumors with poor progno- sis, some progresses have been made in the treatment of this tumor in recent years, mainly referring to concur- rent chemoradiotherapy with temozolomide plus adjuvant temozolomide chemotherapy plus molecule targeted therapy. Although there was no evidence confirming that epidermal growth factor receptor inhibitor has improved the therapeutic effect, other molecular target drugs such as vascular endothelial growth factor receptor inhibitors are being tested in ongoing clinical trials,expecting to further improve the results.