成都地区女性感染人乳头瘤病毒基因型分布

Distribution of genotypes of human papilloma virus infection in women in Chengdu district

目的 探讨成都地区女性感染人乳头瘤病毒（HPV）基因型分布,为预防HPV感染及临床诊治提供实验依据.方法采集1 434例女性宫颈脱落上皮细胞样本,采用基因扩增-导流杂交技术检测.结果 （1）1 434例中HPV感染356例,感染率为24.83%.不同年龄段女性HPV感染率比较,差异有统计学意义（2=23.020,P〈0.05）.（2）感染类型：复合感染率为6.14%,不同年龄段比较,差异有统计学意义（2=7.332,P〈0.05）.单一感染HPV感染率为18.69%.其中高危型、低危型分别为15.48%、3.21%.不同年龄段高危型HPV感染率比较,差异有统计学意义（2=152.700,P〈0.05）.不同年龄段低危型HPV感染率比较,差异无统计学意义（2=2.813,P〉0.05）.（3）最常见高危型为HPV52型,感染率为3.21%.低危型感染主要以HPV11型为主,感染率为1.53%.20～30岁年龄段以感染HPV52为主.31～40岁年龄段以感染HPV16、33为主.41～50岁年龄段以感染HPV16为主.≥51岁HPV感染率低.结论 成都地区受检女性HPV感染率较高,以单一感染及高危感染为主,最常见高危型是HPV52型.不同年龄分层HPV感染亚型分布略有不同.

Objective To discuss the human papillomavirus （HPV） infection in outpatient women in Chengdu district, and to provide a theoretical basis for intervention and prevention of HPV infection. Methods A cluster sampling prevalence analyses were performed during January 2013 to July 2013 among 1434 women attended gynecological clinic. Epithelial cell samples were obtained for subtype screening by HybriMax. Results Positive HPV infections were observed in 356 cases （24.83%）, while there were significant differences in HPV infection rates among different age groups was 18.69%. The high-risk and low-risk HPV subtype infections accounted for 15.48% and 3.21%, respectively. There were significant differences in high-risk P〉0.05）. HPV-52 infection was the most common infection, accounted for 3.21%. HPV-11 was the most common infection among low-risk HPV infection, accounted for 1.53%. HPV-52 was the most common infection in 20~30 age group. HPV-16 and -33 were the most common infections in 31~40 age group. HPV-16 was the most common infection in 41~50 age group. Low HPV-positive rate was observed in subjects over 51. Conclusion The high HPV infection is observed in Chengdu district, among which high-risk HPV and single HPV-52 infection are the most common infections. There is difference in HPV subtype infection among age groups.