子宫内膜异位症与Foxp3关系的研究进展

Development in Research of Endometriosis and Foxp3

子宫内膜异位症是妇科常见良性疾病,主要引起盆腔痛和不孕,目前发病机制不明。近年来关于免疫缺陷与子宫内膜异位症发病之间的关系有不少研究。这其中,调节性T细胞在子宫内膜异位症发病中的作用日益受到重视。CD4+CD25+调节性T细胞是主动免疫抑制反应所必需的。转录因子Foxp3特异性表达于CD4+CD25+调节性T细胞,可作为调节性T细胞的一个特异性标志。Foxp3在CD4+CD25+调节性T细胞生长发育和发挥作用中起关键的调节作用。就转录因子Foxp3的表达与子宫内膜异位症发病之间的关系作综述。

Endometriosis is a common benign gynecologic disease, which causes pelvic pain and infertility, but the pathogenesis is unknown at present. CD4＋CD25＋ regulatory T cells are essential for the active suppression of autoimmunity.Transcription factors Foxp3 expression on CD4＋CD25＋ regulatory T cells specifically, which can be used as a specific symbol of regulatory T cells. Foxp3 is a critical regulator of CD4＋CD25＋ regulatory T cell development and function. The role of regulatory T cells in endometriosis has been paid attention to. In this review,we focus on the relevance between the expression of Foxp3 and the pathogeny of endometriosis.