围绝经期女性潮热与心血管疾病关系的研究进展

Progress of the Relationship between Perimenopausal Hot Flush and Cardiovascular Disease

大多数围绝经期女性伴有潮热症状。目前潮热的发生机制尚未明确,可能与围绝经期女性低雌激素水平引起交感神经活性增强和体温调节机制改变相关。交感神经活性增强可引起血管内皮功能障碍、血压波动、血脂改变及胰岛素抵抗,这些都与心血管疾病的发生密切相关。大量研究表明,围绝经期女性潮热与心血管疾病的发生存在明显的相关性。综述近年潮热发生的病理生理基础,潮热与心血管疾病的关系,以及临床围绝经期激素治疗的研究进展。

Hot flush is complained by three out of four perimenopausal women. The exact etiology of hot flush is unclear,which may underline menopausal-associated hypoestrogenism. The altered sympathetic nervous activity and core body temperature adjust mechanism is also related with menopausal-associated hypoestrogenism. Enhanced sympathetic tone may change vascular endothelial dysfunction,blood pressure,lipids and insulin resistance,which are associated with cardiovascular disease （CVD）. Many researches indicate that perimenopausal hot flush is significantly related to CVD .This article reviews the relation between perimenopausal hot flush and CVD,and the guide role to hormone therapy（HT）.