双歧杆菌三联活菌联合美沙拉嗪治疗溃疡性结肠炎效果分析

Bifidobacterium triple viable combined with mesalazine in treatment of patients with ulcerative colitis

108例初发型轻、中度活动期溃疡性结肠炎（UC）患者,随机分为联合组和对照组各59例,对照组采用餐后口服美沙拉嗪（1.0 g/次、4次/d）联合组加用双歧杆菌三联活菌（420 mg/次、3次/d）治疗,疗程2个月.结果显示,联合组治疗后活动度显著降低,Mayo指数低于对照组（P=0.028）,治疗效果优于对照组（P=0.024）.两组治疗后血清肿瘤坏死因子-α（TNF-α）、IL-6、IL-8水平均较治疗前显著降低,血清IL-10水平较治疗前显著升高（P＜0.05）;治疗后联合组与对照组血清TNF-α、IL-6、IL-8、IL-10水平差异均有统计学意义（P＜0.05）.两组治疗后血清超氧化物歧化酶（SOD）水平均较治疗前显著降低,血清丙二醛（MDA）水平显著升高（P＜0.05）;治疗后联合组与对照组血清SOD、MDA水平差异均有统计学意义（P＜0.05）.提示双歧杆菌三联活菌联合美沙拉嗪较单用美沙拉嗪更有效地抑制UC炎性反应和氧化应激,从而降低UC活动度,提高治疗效果.

One hundred and eight patients with early onset mild or moderate active ulcerative colitis （UC） were randomly divided into combination group and control group. Patients in combination group were treated with postprandial oral mesalazine （ 1.0 g, q. i. d） and bifidobacterium triple viable capsule （420 rag, t. i. d） for 2 months, and those in control group were treated with postprandial oral mesalazine alone （ 1.0 g, q. i. d） for 2 months. Results showed that the Mayo index in combination group was significantly lower than that in control group （ P = 0. 028 ） after treatment ; and the clinical efficacy was significantly better than that of control group （ P = 0. 024） . After treatment, serum TNF-α, IL-6, IL-8 levels in both groups were significantly lower and IL-10 level was significantly higher （ P 〈 0. 05 ） than those before treatment. Therewere significant differences in serum TNF-α, IL-6, IL-8, IL-IO levels after treatment between combination group and control group （P 〈 0.05 ）. After treatment, serum SOD levels were significantly reduced and MDA levels were significantly increased compared to those before treatment （ both P 〈 0. 05 ）. There were significant differences in serum SOD and MDA levels after treatment between two groups （ P 〈 O. 05 ）. Bifidobacterium triple viable combined with mesalazine shows more effective in inhibition of UC-inflammatory response and oxidative stress, resultin~ in reduction of UC activity and improvement of therapeutic effect.